We calculate the power spectra of primordial curvature and isocurvature perturbations from a general two-field inflation model at next-to-leading order correction in a slow-roll expansion. In particular we calculate the spectral indices to second order in slow-roll parameters. We show that the cross correlation of the curvature and isocurvature perturbations at the time of Hubble exit during inflation is nonzero at first order in slow-roll parameters. We apply our results to different classes of inflation, including inflaton and curvaton scenarios. The spectrum of primordial gravitational waves, curvature and isocurvature perturbations obey generalized consistency relations in two-field inflation models. We give the first two consistency relations in an infinite hierarchy.