Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies

Anup Das, Mainul Haque, Marc Chikhani, Wenfei Wang, Tayyba Ali, Oana Cole, Jonathan G. Hardman, Declan G. Bates

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We describe the development of an integrated cardiovascular and pulmonary model for use in the investigation of novel mechanical ventilation strategies in the intensive care unit. The cardiac model includes the cardiac chambers, the pulmonary circulation and the systemic circulation. The modeling of complex mechanisms for vascular segments, time varying elastance functions of cardiovascular components and the effect of vascular resistances, in health and disease under the influence of mechanical ventilation is investigated. The resulting biomedical simulator can aid in understanding the underlying pathophysiology of critically-ill patients and facilitate the development of more effective therapeutic strategies for evaluation in clinical trials.
Original languageEnglish
Title of host publication2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
PublisherIEEE
Pages5319-5322
ISBN (Electronic)978-1-4244-9271-8
ISBN (Print)9781424492695
DOIs
Publication statusPublished - 5 Nov 2015
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Milan, Italy
Duration: 25 Aug 201529 Aug 2015
https://embc.embs.org/2015/

Publication series

NameIEEE EMBC Proceedings Series
PublisherIEEE
ISSN (Print)1558-4615
ISSN (Electronic)1094-687X

Conference

Conference37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Abbreviated titleEMBC 2015
Country/TerritoryItaly
CityMilan
Period25/08/1529/08/15
Internet address

Keywords

  • RCUK
  • MRC
  • G1002017
  • MR/K019783

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