Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies

Anup Das; Mainul Haque; Marc Chikhani; Wenfei Wang; Tayyba Ali; Oana Cole; Jonathan G. Hardman; Declan G. Bates

doi:10.1109/EMBC.2015.7319592

Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies

Anup Das, Mainul Haque, Marc Chikhani, Wenfei Wang, Tayyba Ali, Oana Cole, Jonathan G. Hardman, Declan G. Bates

School of Mathematics & Physics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We describe the development of an integrated cardiovascular and pulmonary model for use in the investigation of novel mechanical ventilation strategies in the intensive care unit. The cardiac model includes the cardiac chambers, the pulmonary circulation and the systemic circulation. The modeling of complex mechanisms for vascular segments, time varying elastance functions of cardiovascular components and the effect of vascular resistances, in health and disease under the influence of mechanical ventilation is investigated. The resulting biomedical simulator can aid in understanding the underlying pathophysiology of critically-ill patients and facilitate the development of more effective therapeutic strategies for evaluation in clinical trials.

Original language	English
Title of host publication	2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	5319-5322
ISBN (Electronic)	978-1-4244-9271-8
ISBN (Print)	9781424492695
DOIs	https://doi.org/10.1109/EMBC.2015.7319592
Publication status	Published - 5 Nov 2015
Event	37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Milan, Italy Duration: 25 Aug 2015 → 29 Aug 2015 https://embc.embs.org/2015/

Publication series

Name	IEEE EMBC Proceedings Series
Publisher	IEEE
ISSN (Print)	1558-4615
ISSN (Electronic)	1094-687X

Conference

Conference	37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Abbreviated title	EMBC 2015
Country/Territory	Italy
City	Milan
Period	25/08/15 → 29/08/15
Internet address	https://embc.embs.org/2015/

Keywords

RCUK
MRC
G1002017
MR/K019783

Access to Document

10.1109/EMBC.2015.7319592

http://ieeexplore.ieee.org/document/7319592/

Cite this

Das, A., Haque, M., Chikhani, M., Wang, W., Ali, T., Cole, O., Hardman, J. G., & Bates, D. G. (2015). Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies. In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (pp. 5319-5322). (IEEE EMBC Proceedings Series). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2015.7319592

Das, Anup ; Haque, Mainul ; Chikhani, Marc et al. / Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies. 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Institute of Electrical and Electronics Engineers Inc., 2015. pp. 5319-5322 (IEEE EMBC Proceedings Series).

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title = "Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies",

abstract = "We describe the development of an integrated cardiovascular and pulmonary model for use in the investigation of novel mechanical ventilation strategies in the intensive care unit. The cardiac model includes the cardiac chambers, the pulmonary circulation and the systemic circulation. The modeling of complex mechanisms for vascular segments, time varying elastance functions of cardiovascular components and the effect of vascular resistances, in health and disease under the influence of mechanical ventilation is investigated. The resulting biomedical simulator can aid in understanding the underlying pathophysiology of critically-ill patients and facilitate the development of more effective therapeutic strategies for evaluation in clinical trials.",

keywords = "RCUK, MRC, G1002017, MR/K019783",

author = "Anup Das and Mainul Haque and Marc Chikhani and Wenfei Wang and Tayyba Ali and Oana Cole and Hardman, {Jonathan G.} and Bates, {Declan G.}",

note = "Post-print unavailable; 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 ; Conference date: 25-08-2015 Through 29-08-2015",

year = "2015",

month = nov,

day = "5",

doi = "10.1109/EMBC.2015.7319592",

language = "English",

isbn = "9781424492695",

series = "IEEE EMBC Proceedings Series",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "5319--5322",

booktitle = "2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)",

address = "United States",

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}

Das, A, Haque, M, Chikhani, M, Wang, W, Ali, T, Cole, O, Hardman, JG & Bates, DG 2015, Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies. in 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE EMBC Proceedings Series, Institute of Electrical and Electronics Engineers Inc., pp. 5319-5322, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Milan, Italy, 25/08/15. https://doi.org/10.1109/EMBC.2015.7319592

Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies. / Das, Anup; Haque, Mainul; Chikhani, Marc et al.
2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Institute of Electrical and Electronics Engineers Inc., 2015. p. 5319-5322 (IEEE EMBC Proceedings Series).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies

AU - Das, Anup

AU - Haque, Mainul

AU - Chikhani, Marc

AU - Wang, Wenfei

AU - Ali, Tayyba

AU - Cole, Oana

AU - Hardman, Jonathan G.

AU - Bates, Declan G.

N1 - Post-print unavailable

PY - 2015/11/5

Y1 - 2015/11/5

N2 - We describe the development of an integrated cardiovascular and pulmonary model for use in the investigation of novel mechanical ventilation strategies in the intensive care unit. The cardiac model includes the cardiac chambers, the pulmonary circulation and the systemic circulation. The modeling of complex mechanisms for vascular segments, time varying elastance functions of cardiovascular components and the effect of vascular resistances, in health and disease under the influence of mechanical ventilation is investigated. The resulting biomedical simulator can aid in understanding the underlying pathophysiology of critically-ill patients and facilitate the development of more effective therapeutic strategies for evaluation in clinical trials.

AB - We describe the development of an integrated cardiovascular and pulmonary model for use in the investigation of novel mechanical ventilation strategies in the intensive care unit. The cardiac model includes the cardiac chambers, the pulmonary circulation and the systemic circulation. The modeling of complex mechanisms for vascular segments, time varying elastance functions of cardiovascular components and the effect of vascular resistances, in health and disease under the influence of mechanical ventilation is investigated. The resulting biomedical simulator can aid in understanding the underlying pathophysiology of critically-ill patients and facilitate the development of more effective therapeutic strategies for evaluation in clinical trials.

KW - RCUK

KW - MRC

KW - G1002017

KW - MR/K019783

U2 - 10.1109/EMBC.2015.7319592

DO - 10.1109/EMBC.2015.7319592

M3 - Conference contribution

SN - 9781424492695

T3 - IEEE EMBC Proceedings Series

SP - 5319

EP - 5322

BT - 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Y2 - 25 August 2015 through 29 August 2015

ER -

Das A, Haque M, Chikhani M, Wang W, Ali T, Cole O et al. Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies. In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Institute of Electrical and Electronics Engineers Inc. 2015. p. 5319-5322. (IEEE EMBC Proceedings Series). doi: 10.1109/EMBC.2015.7319592

Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies

Abstract

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Keywords

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