Directed formation of DNA Nanoarrays through Orthogonal Self-Assembly

Jonathan R. Burns; Jurgita Zekonyte; Giuliano Siligardi; Rohanah Hussain; Eugen Stulz

doi:10.3390/molecules16064912

Directed formation of DNA Nanoarrays through Orthogonal Self-Assembly

Jonathan R. Burns, Jurgita Zekonyte, Giuliano Siligardi, Rohanah Hussain, Eugen Stulz

Research output: Contribution to journal › Article › peer-review

Abstract

We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self-assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II) and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers.

Original language	English
Pages (from-to)	4912-4922
Journal	Molecules
Volume	16
Issue number	6
DOIs	https://doi.org/10.3390/molecules16064912
Publication status	Published - Jun 2011

Keywords

terpy-DNA
AFM
TEM
DNA nanotubes

Access to Document

10.3390/molecules16064912

Cite this

@article{83dd3db5f6974e4baa64c044ebea39e2,

title = "Directed formation of DNA Nanoarrays through Orthogonal Self-Assembly",

abstract = "We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self-assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II) and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers. ",

keywords = "terpy-DNA, AFM, TEM, DNA nanotubes",

author = "Burns, {Jonathan R.} and Jurgita Zekonyte and Giuliano Siligardi and Rohanah Hussain and Eugen Stulz",

year = "2011",

month = jun,

doi = "10.3390/molecules16064912",

language = "English",

volume = "16",

pages = "4912--4922",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute",

number = "6",

}

TY - JOUR

T1 - Directed formation of DNA Nanoarrays through Orthogonal Self-Assembly

AU - Burns, Jonathan R.

AU - Zekonyte, Jurgita

AU - Siligardi, Giuliano

AU - Hussain, Rohanah

AU - Stulz, Eugen

PY - 2011/6

Y1 - 2011/6

N2 - We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self-assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II) and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers.

AB - We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self-assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II) and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers.

KW - terpy-DNA

KW - AFM

KW - TEM

KW - DNA nanotubes

U2 - 10.3390/molecules16064912

DO - 10.3390/molecules16064912

M3 - Article

SN - 1420-3049

VL - 16

SP - 4912

EP - 4922

JO - Molecules

JF - Molecules

IS - 6

ER -

Directed formation of DNA Nanoarrays through Orthogonal Self-Assembly

Abstract

Keywords

Access to Document

Fingerprint

Cite this