DNA methylation models histone acetylation

S. Eden, I. Hashimshony, H. Keshet, H. Cedar, Alan Thorne

    Research output: Contribution to journalArticlepeer-review

    Abstract

    One of the main determinants of chromatin structure is histone acetylation1. Local chromosomal acetylation can be regulated dynamically, both through the involvement of transactivating factors with intrinsic histone acetylase activity, and through the recruitment of deacetylase complexes that repress gene expression2. Histone acetylation status is transiently modified from one state to another in response to physiological changes operating in the cell. It is not yet known, however, how the basic histone acetylation profiles on tissue-specific and housekeeping gene sequences are established during normal development. Here we show that DNA methylation takes part in this process by inducing decreased levels of chromatin acetylation.
    Original languageEnglish
    Pages (from-to)842
    Number of pages1
    JournalNature
    Volume394
    Issue number6696
    DOIs
    Publication statusPublished - 1998

    Fingerprint

    Dive into the research topics of 'DNA methylation models histone acetylation'. Together they form a unique fingerprint.

    Cite this