Abstract
The non-viral vectors and targeting methods offer some specific advantages. These include better safety profiles (lower toxicity and non-infectious properties) and the capacity to transfer large genes and low production costs. The clinical usefulness of non-viral methods has been hindered by their relatively low gene delivery and transgene expression efficiencies. However, recent problems in clinical trials using viral vectors renewed interest in non-viral technologies, particularly that the properties of non-viral vectors make them appear closer to the traditional pharmaceutics.
Original language | English |
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Pages (from-to) | 191-197 |
Number of pages | 7 |
Journal | Discovery Medicine |
Volume | 6 |
Issue number | 35 |
Publication status | Published - 2006 |