"Dressed-up" naked plasmids: emerging vectors for non-viral gene therapy

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The non-viral vectors and targeting methods offer some specific advantages. These include better safety profiles (lower toxicity and non-infectious properties) and the capacity to transfer large genes and low production costs. The clinical usefulness of non-viral methods has been hindered by their relatively low gene delivery and transgene expression efficiencies. However, recent problems in clinical trials using viral vectors renewed interest in non-viral technologies, particularly that the properties of non-viral vectors make them appear closer to the traditional pharmaceutics.
    Original languageEnglish
    Pages (from-to)191-197
    Number of pages7
    JournalDiscovery Medicine
    Volume6
    Issue number35
    Publication statusPublished - 2006

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