Dual-stimuli-responsive hydrogels based on poly(N-isopropylacrylamide)/chitosan semi-interpenetrating networks

Liliana Verestiuc; Claudia Ivanov; Eugen Barbu; John Tsibouklis

doi:10.1016/j.ijpharm.2003.09.031

Dual-stimuli-responsive hydrogels based on poly(N-isopropylacrylamide)/chitosan semi-interpenetrating networks

Liliana Verestiuc, Claudia Ivanov, Eugen Barbu, John Tsibouklis

Institute of Life Sciences and Healthcare

Grigore T. Popa University of Medicine and Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis and characterisation of semi-interpenetrating polymeric networks obtained by the radical-induced polymerisation of N-isopropylacrylamide in the presence of chitosan using tetraethyleneglycoldiacrylate as the crosslinker is described. The influence of the degree of crosslinking and that of the ratio of chitosan to poly(N-isopropylacrylamide) on the “pH/temperature induced” phase transition behaviour and swelling characteristics of the hydrogel system are investigated. The ability of the same system to act as a controlled release vehicle for pilocarpine hydrochloride is evaluated.

Original language	English
Pages (from-to)	185-194
Journal	International Journal of Pharmaceutics
Volume	269
Issue number	1
Early online date	21 Nov 2003
DOIs	https://doi.org/10.1016/j.ijpharm.2003.09.031
Publication status	Published - 9 Jan 2004

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10.1016/j.ijpharm.2003.09.031

http://linkinghub.elsevier.com/retrieve/pii/S0378517303005349

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title = "Dual-stimuli-responsive hydrogels based on poly(N-isopropylacrylamide)/chitosan semi-interpenetrating networks",

abstract = "The synthesis and characterisation of semi-interpenetrating polymeric networks obtained by the radical-induced polymerisation of N-isopropylacrylamide in the presence of chitosan using tetraethyleneglycoldiacrylate as the crosslinker is described. The influence of the degree of crosslinking and that of the ratio of chitosan to poly(N-isopropylacrylamide) on the “pH/temperature induced” phase transition behaviour and swelling characteristics of the hydrogel system are investigated. The ability of the same system to act as a controlled release vehicle for pilocarpine hydrochloride is evaluated.",

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AU - Verestiuc, Liliana

AU - Ivanov, Claudia

AU - Barbu, Eugen

AU - Tsibouklis, John

PY - 2004/1/9

Y1 - 2004/1/9

N2 - The synthesis and characterisation of semi-interpenetrating polymeric networks obtained by the radical-induced polymerisation of N-isopropylacrylamide in the presence of chitosan using tetraethyleneglycoldiacrylate as the crosslinker is described. The influence of the degree of crosslinking and that of the ratio of chitosan to poly(N-isopropylacrylamide) on the “pH/temperature induced” phase transition behaviour and swelling characteristics of the hydrogel system are investigated. The ability of the same system to act as a controlled release vehicle for pilocarpine hydrochloride is evaluated.

AB - The synthesis and characterisation of semi-interpenetrating polymeric networks obtained by the radical-induced polymerisation of N-isopropylacrylamide in the presence of chitosan using tetraethyleneglycoldiacrylate as the crosslinker is described. The influence of the degree of crosslinking and that of the ratio of chitosan to poly(N-isopropylacrylamide) on the “pH/temperature induced” phase transition behaviour and swelling characteristics of the hydrogel system are investigated. The ability of the same system to act as a controlled release vehicle for pilocarpine hydrochloride is evaluated.

U2 - 10.1016/j.ijpharm.2003.09.031

DO - 10.1016/j.ijpharm.2003.09.031

M3 - Article

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SP - 185

EP - 194

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1

ER -

Dual-stimuli-responsive hydrogels based on poly(N-isopropylacrylamide)/chitosan semi-interpenetrating networks

Abstract

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