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Abstract
We report an investigation of the mutations dynamics of the SARS-CoV-2 virus using Shannon’s information theory. Our study includes seventeen RNA genetic sequences collected at different geographic locations and timeframes ranging from Dec. 2019 to Oct. 2021. The data shows a previously unobserved relationship between the information entropy of genomes and their mutation dynamics. The information entropy of the mutated variants decreases linearly with the number of genetic mutations with a negative slope of 1.52 x 10 to power -5 bits / mutations, pointing to a possible deterministic approach to the dynamics of genetic mutations. The method proposed here could be used to develop a predictive algorithm of genetic mutations.
| Original language | English |
|---|---|
| Publisher | bioRxiv |
| Pages | 1-6 |
| Number of pages | 6 |
| DOIs | |
| Publication status | Published - 14 Jun 2022 |
Keywords
- genetic mutations
- information theory
- entropy of information
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A possible information entropic law of genetic mutations
Vopson, M., 8 Jul 2022, In: Applied Sciences (Switzerland). 12, 14, 8 p., 6912.Research output: Contribution to journal › Article › peer-review
Open AccessFile129 Downloads (Pure) -
Second law of information dynamics
Vopson, M. & Lepadatu, S., 11 Jul 2022, In: AIP Advances. 12, 7, 6 p., 075310.Research output: Contribution to journal › Article › peer-review
Open AccessFile546 Downloads (Pure) -
A new method to study genome mutations using the information entropy
Vopson, M. & Robson, S., 27 May 2021, bioRxiv, 12 p.Research output: Working paper
Open AccessFile206 Downloads (Pure) -
A new method to study genome mutations using the information entropy
Vopson, M. & Robson, S., 15 Dec 2021, In: Physica A: Statistical Mechanics and its Applications. 584, 9 p., 126383.Research output: Contribution to journal › Article › peer-review
Open AccessFile69 Downloads (Pure)
Projects
- 1 Active
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Information Physics Institute (External organisation)
Melvin Vopson (Chair), Anna Vopson (Chair) & Serban Lepadatu (Member)
15 Sept 2022Activity: Membership types › Membership of board
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Applied Sciences (Switzerland) (Journal)
Melvin Vopson (Guest editor) & Jaewoo Joo (Guest editor)
1 Jul 2021 → 31 Dec 2021Activity: Publication peer-review and editorial work types › Editorial activity
Press/Media
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Could a mathematical application of information theory identify and predict SARS-CoV-2 mutations?
31/05/21
1 item of Media coverage
Press/Media: Research cited