Effect of meal on retinal blood flow in IDDM patients

P. M. Sullivan; V. J. Parfitt; R. Jagoe; R. Newsom; E. M. Kohner

doi:10.2337/diacare.14.8.756

Effect of meal on retinal blood flow in IDDM patients

P. M. Sullivan, V. J. Parfitt, R. Jagoe, R. Newsom, E. M. Kohner^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: The effect of postprandial hyperglycemia on retinal blood flow was examined in 11 adults with insulin-dependent diabetes mellitus (IDDM) and 9 nondiabetic subjects. Research Design and Methods: Retinal blood flow was measured with bidirectional laser Doppler velocimetry before and 60 and 120 min after a 50-g carbohydrate breakfast. Diabetic subjects were studied twice, being randomized to take their usual insulin (isoglycemic study) or to omit their morning short-acting insulin (hyperglycemic study). Nondiabetic subjects were studied once and received no insulin. Results: Plasma glucose rose significantly (from 11.5 ± 5.2 to 22.1 ± 5.5 mM, P < 0.001) during the hyperglycemic study but not during the isoglycemic or nondiabetic studies. There were no significant changes in blood pressure or retinal blood flow in any of the groups studied. Conclusions: Short-term hyperglycemia does not increase retinal blood flow.

Original language	English
Pages (from-to)	756-758
Number of pages	3
Journal	Diabetes Care
Volume	14
Issue number	8
DOIs	https://doi.org/10.2337/diacare.14.8.756
Publication status	Published - 1 Aug 1991

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title = "Effect of meal on retinal blood flow in IDDM patients",

abstract = "Objective: The effect of postprandial hyperglycemia on retinal blood flow was examined in 11 adults with insulin-dependent diabetes mellitus (IDDM) and 9 nondiabetic subjects. Research Design and Methods: Retinal blood flow was measured with bidirectional laser Doppler velocimetry before and 60 and 120 min after a 50-g carbohydrate breakfast. Diabetic subjects were studied twice, being randomized to take their usual insulin (isoglycemic study) or to omit their morning short-acting insulin (hyperglycemic study). Nondiabetic subjects were studied once and received no insulin. Results: Plasma glucose rose significantly (from 11.5 ± 5.2 to 22.1 ± 5.5 mM, P < 0.001) during the hyperglycemic study but not during the isoglycemic or nondiabetic studies. There were no significant changes in blood pressure or retinal blood flow in any of the groups studied. Conclusions: Short-term hyperglycemia does not increase retinal blood flow.",

author = "Sullivan, {P. M.} and Parfitt, {V. J.} and R. Jagoe and R. Newsom and Kohner, {E. M.}",

year = "1991",

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doi = "10.2337/diacare.14.8.756",

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T1 - Effect of meal on retinal blood flow in IDDM patients

AU - Sullivan, P. M.

AU - Parfitt, V. J.

AU - Jagoe, R.

AU - Newsom, R.

AU - Kohner, E. M.

PY - 1991/8/1

Y1 - 1991/8/1

N2 - Objective: The effect of postprandial hyperglycemia on retinal blood flow was examined in 11 adults with insulin-dependent diabetes mellitus (IDDM) and 9 nondiabetic subjects. Research Design and Methods: Retinal blood flow was measured with bidirectional laser Doppler velocimetry before and 60 and 120 min after a 50-g carbohydrate breakfast. Diabetic subjects were studied twice, being randomized to take their usual insulin (isoglycemic study) or to omit their morning short-acting insulin (hyperglycemic study). Nondiabetic subjects were studied once and received no insulin. Results: Plasma glucose rose significantly (from 11.5 ± 5.2 to 22.1 ± 5.5 mM, P < 0.001) during the hyperglycemic study but not during the isoglycemic or nondiabetic studies. There were no significant changes in blood pressure or retinal blood flow in any of the groups studied. Conclusions: Short-term hyperglycemia does not increase retinal blood flow.

AB - Objective: The effect of postprandial hyperglycemia on retinal blood flow was examined in 11 adults with insulin-dependent diabetes mellitus (IDDM) and 9 nondiabetic subjects. Research Design and Methods: Retinal blood flow was measured with bidirectional laser Doppler velocimetry before and 60 and 120 min after a 50-g carbohydrate breakfast. Diabetic subjects were studied twice, being randomized to take their usual insulin (isoglycemic study) or to omit their morning short-acting insulin (hyperglycemic study). Nondiabetic subjects were studied once and received no insulin. Results: Plasma glucose rose significantly (from 11.5 ± 5.2 to 22.1 ± 5.5 mM, P < 0.001) during the hyperglycemic study but not during the isoglycemic or nondiabetic studies. There were no significant changes in blood pressure or retinal blood flow in any of the groups studied. Conclusions: Short-term hyperglycemia does not increase retinal blood flow.

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JO - Diabetes Care

JF - Diabetes Care

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Effect of meal on retinal blood flow in IDDM patients

Abstract

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