Effect of meal on retinal blood flow in IDDM patients

P. M. Sullivan, V. J. Parfitt, R. Jagoe, R. Newsom, E. M. Kohner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: The effect of postprandial hyperglycemia on retinal blood flow was examined in 11 adults with insulin-dependent diabetes mellitus (IDDM) and 9 nondiabetic subjects. Research Design and Methods: Retinal blood flow was measured with bidirectional laser Doppler velocimetry before and 60 and 120 min after a 50-g carbohydrate breakfast. Diabetic subjects were studied twice, being randomized to take their usual insulin (isoglycemic study) or to omit their morning short-acting insulin (hyperglycemic study). Nondiabetic subjects were studied once and received no insulin. Results: Plasma glucose rose significantly (from 11.5 ± 5.2 to 22.1 ± 5.5 mM, P < 0.001) during the hyperglycemic study but not during the isoglycemic or nondiabetic studies. There were no significant changes in blood pressure or retinal blood flow in any of the groups studied. Conclusions: Short-term hyperglycemia does not increase retinal blood flow.

Original languageEnglish
Pages (from-to)756-758
Number of pages3
JournalDiabetes Care
Issue number8
Publication statusPublished - 1 Aug 1991


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