Effects of baclofen and ghrelin on food intake in non-deprived rats

Ivor Ebenezer

Research output: Contribution to journalArticlepeer-review

Abstract

There are a number of similarities between the effects of the GABAB receptor agonist baclofen (bac) and the gut peptide ghrelin on food intake. For example, both drugs increase food intake in non-deprived rats after central or systemic administration but not in food-deprived rats (see Ebenezer et al., 2011 Wren et al., 2000). Furthermore, preliminary results from our laboratory indicate that systemic administration of bac elevates blood plasma levels of ghrelin in rats (Bains, Shute and Ebenezer, unpublished results) The present study was conducted to examine if submaximal doses of i.p. bac and ghrelin. interact synergistically to potentiate food intake.
Original languageEnglish
JournalpA2 online
Volume10
Issue number4
Publication statusPublished - 2012
EventBPS Winter Meeting 2012 - Queen Elizabeth II Conference Centre, London
Duration: 1 Jan 2012 → …

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