There are a number of similarities between the effects of the GABAB receptor agonist baclofen (bac) and the gut peptide ghrelin on food intake. For example, both drugs increase food intake in non-deprived rats after central or systemic administration but not in food-deprived rats (see Ebenezer et al., 2011 Wren et al., 2000). Furthermore, preliminary results from our laboratory indicate that systemic administration of bac elevates blood plasma levels of ghrelin in rats (Bains, Shute and Ebenezer, unpublished results) The present study was conducted to examine if submaximal doses of i.p. bac and ghrelin. interact synergistically to potentiate food intake.