Effects of hexamethonium and mecamylamine on baclofen-induced hyperphagia in non-deprived rats

Ivor Ebenezer, A. Cecchinato, K. Atmani

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Abstract

We have previously demonstrated that systemic administration of the GABAB receptor agonist baclofen (bac) increases food intake in non-deprived rats by a central mechanism of action (see Ebenezer et al., 2004). As part of a continuing programme to investigate possible interactions of bac with central neurotransmitter / neuromodulator systems on ingestive behaviour, the present study was undertaken to examine the effects of the peripherally and centrally active nicotinic acetylcholine (ACh) receptor antagonists hexamethonium (hexa) and mecamylamine (meca) respectively on bac-induced hyperphagia.
Original languageEnglish
JournalpA2 online
Volume10
Issue number4
Publication statusPublished - 2012

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