Effects of intraperitoneal administration of the GABAB receptor positive allosteric modulator 2,6-di tert-butyl-4-(2-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) on food intake in non-deprived rats

Ivor Ebenezer

Research output: Contribution to journalArticlepeer-review

Abstract

γ-Aminobutyric acid-B (GABAB) receptor positive allosteric modulators (PAMs) act on an allosteric site on the GABAB receptor to potentiate the effects of GABA and GABAB receptor agonists. It has previously been demonstrated that the GABAB receptor agonist baclofen increases food intake in non-deprived rats. The aim of this study was to investigate whether the GABAB receptor PAM 2,6-di tert-butyl-4-(2-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) would (i) increase food intake, and (ii) potentiate the hyperphagic effects of baclofen in rats. In Experiment 1, the effects of intraperitoneal (i.p.) administration of CGP7930 (1, 6 and 12 mg/kg) was investigated on food intake in non-deprived male Wistar rats. The 12 mg/kg dose of CGP7930 significantly increased cumulative food intake 30, 60 and 120 min (P
Original languageEnglish
Pages (from-to)115-118
Number of pages4
JournalEuropean Journal of Pharmacology
Volume690
Issue number1-3
DOIs
Publication statusPublished - 5 Sep 2012

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