TY - JOUR
T1 - Effects of intraperitoneal administration of the GABAB receptor positive allosteric modulator 2,6-di tert-butyl-4-(2-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) on food intake in non-deprived rats
AU - Ebenezer, Ivor
PY - 2012/9/5
Y1 - 2012/9/5
N2 - γ-Aminobutyric acid-B (GABAB) receptor positive allosteric modulators (PAMs) act on an allosteric site on the GABAB receptor to potentiate the effects of GABA and GABAB receptor agonists. It has previously been demonstrated that the GABAB receptor agonist baclofen increases food intake in non-deprived rats. The aim of this study was to investigate whether the GABAB receptor PAM 2,6-di tert-butyl-4-(2-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) would (i) increase food intake, and (ii) potentiate the hyperphagic effects of baclofen in rats. In Experiment 1, the effects of intraperitoneal (i.p.) administration of CGP7930 (1, 6 and 12 mg/kg) was investigated on food intake in non-deprived male Wistar rats. The 12 mg/kg dose of CGP7930 significantly increased cumulative food intake 30, 60 and 120 min (P
AB - γ-Aminobutyric acid-B (GABAB) receptor positive allosteric modulators (PAMs) act on an allosteric site on the GABAB receptor to potentiate the effects of GABA and GABAB receptor agonists. It has previously been demonstrated that the GABAB receptor agonist baclofen increases food intake in non-deprived rats. The aim of this study was to investigate whether the GABAB receptor PAM 2,6-di tert-butyl-4-(2-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) would (i) increase food intake, and (ii) potentiate the hyperphagic effects of baclofen in rats. In Experiment 1, the effects of intraperitoneal (i.p.) administration of CGP7930 (1, 6 and 12 mg/kg) was investigated on food intake in non-deprived male Wistar rats. The 12 mg/kg dose of CGP7930 significantly increased cumulative food intake 30, 60 and 120 min (P
U2 - 10.1016/j.ejphar.2012.05.021
DO - 10.1016/j.ejphar.2012.05.021
M3 - Article
SN - 0014-2999
VL - 690
SP - 115
EP - 118
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-3
ER -