Efficacy of 10% sucralfate ointment in the reduction of acute postoperative pain after open hemorrhoidectomy: a prospective, double-blind, randomized, placebo-controlled trial

Shahram Ala*, Majid Saeedi, Fariborz Eshghi, Vahid Hejazi, Mohammadreza Rafati, Roja Hadianamrei

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: The aim of the present study was to evaluate the efficacy of 10 % sucralfate ointment in the reduction of acute postoperative pain after open hemorrhoidectomy.

Methods: A total of 48 patients (24 men and 24 women) between 20 and 70 years of age who underwent open hemorrhoidectomy were included in this prospective, double-blind, randomized, controlled trial and were randomly divided into two groups (24 in each group), receiving either sucralfate ointment or placebo immediately after surgery and then every 12 h for 14 days. The primary outcome measure was pain intensity measured by a visual analogue scale at different time points after hemorrhoidectomy.

Results: The sucralfate group had significantly less pain than the placebo group at 24th h and the 48th h after hemorrhoidectomy (4 ± 1.14 vs 5.08 ± 0.97; P = 0.001 and 3 ± 0.72 vs 4.41 ± 0.8; P < 0.001, respectively), and they consumed lower amounts of analgesics at the same time intervals (12.50 ± 16.48 vs 21.87 ± 15.30 mg of pethidine; P = 0.047 and 152 ± 23 vs 172 ± 29 mg of diclofenac; P = 0.009, respectively). The same trend continued until the end of the trial.

Conclusions: Sucralfate ointment reduced the acute postoperative pain after hemorrhoidectomy.
Original languageEnglish
Pages (from-to)233-238
Number of pages6
JournalWorld Journal of Surgery
Issue number1
Early online date26 Sept 2012
Publication statusPublished - 1 Jan 2013

Cite this