Encapsulation of a radiolabeled cluster inside a fullerene cage, 177LuxLu(3−x)N@C80: an interleukin-13-conjugated radiolabeled metallofullerene platform

M. Shultz, J. Duchamp, John D. Wilson, C. Shu, Jiechao Ge, J. Zhang, H. Gibson, Helen Fillmore, J. Hirsch, H. Dorn, P. Fatouros

Research output: Contribution to journalArticlepeer-review

Abstract

In this communication, we describe the successful encapsulation of 177Lu into the endohedral metallofullerene 177LuxLu3−xN@C80 (x = 1−3) starting with 177LuCl3 in a modified quartz Kräschmer−Huffman electric generator. We demonstrate that the 177Lu (β-emitter) in this fullerene cage is not significantly released for a period of up to at least one-half-life (6.7 days). We also demonstrate that this agent can be conjugated with an interleukin-13 peptide that is designed to target an overexpressed receptor in glioblastoma multiforme tumors. This nanoparticle delivery platform provides flexibility for a wide range of radiotherapeutic and radiodiagnostic multimodal applications.
Original languageEnglish
Pages (from-to)4980-4981
Number of pages2
JournalJournal of the American Chemical Society
Volume132
Issue number14
DOIs
Publication statusPublished - 2010

Fingerprint

Dive into the research topics of 'Encapsulation of a radiolabeled cluster inside a fullerene cage, 177LuxLu(3−x)N@C80: an interleukin-13-conjugated radiolabeled metallofullerene platform'. Together they form a unique fingerprint.

Cite this