Encapsulation of a radiolabeled cluster inside a fullerene cage, 177LuxLu(3−x)N@C80: an interleukin-13-conjugated radiolabeled metallofullerene platform

M. Shultz; J. Duchamp; John D. Wilson; C. Shu; Jiechao Ge; J. Zhang; H. Gibson; Helen Fillmore; J. Hirsch; H. Dorn; P. Fatouros

doi:10.1021/ja9093617

Encapsulation of a radiolabeled cluster inside a fullerene cage, 177LuxLu(3−x)N@C80: an interleukin-13-conjugated radiolabeled metallofullerene platform

M. Shultz, J. Duchamp, John D. Wilson, C. Shu, Jiechao Ge, J. Zhang, H. Gibson, Helen Fillmore, J. Hirsch, H. Dorn, P. Fatouros

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Abstract

In this communication, we describe the successful encapsulation of 177Lu into the endohedral metallofullerene 177LuxLu3−xN@C80 (x = 1−3) starting with 177LuCl3 in a modified quartz Kräschmer−Huffman electric generator. We demonstrate that the 177Lu (β-emitter) in this fullerene cage is not significantly released for a period of up to at least one-half-life (6.7 days). We also demonstrate that this agent can be conjugated with an interleukin-13 peptide that is designed to target an overexpressed receptor in glioblastoma multiforme tumors. This nanoparticle delivery platform provides flexibility for a wide range of radiotherapeutic and radiodiagnostic multimodal applications.

Original language	English
Pages (from-to)	4980-4981
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	132
Issue number	14
DOIs	https://doi.org/10.1021/ja9093617
Publication status	Published - 2010

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Shultz, M., Duchamp, J., Wilson, J. D., Shu, C., Ge, J., Zhang, J., Gibson, H., Fillmore, H., Hirsch, J., Dorn, H., & Fatouros, P. (2010). Encapsulation of a radiolabeled cluster inside a fullerene cage, 177LuxLu(3−x)N@C80: an interleukin-13-conjugated radiolabeled metallofullerene platform. Journal of the American Chemical Society, 132(14), 4980-4981. https://doi.org/10.1021/ja9093617

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title = "Encapsulation of a radiolabeled cluster inside a fullerene cage, 177LuxLu(3−x)N@C80: an interleukin-13-conjugated radiolabeled metallofullerene platform",

abstract = "In this communication, we describe the successful encapsulation of 177Lu into the endohedral metallofullerene 177LuxLu3−xN@C80 (x = 1−3) starting with 177LuCl3 in a modified quartz Kr{\"a}schmer−Huffman electric generator. We demonstrate that the 177Lu (β-emitter) in this fullerene cage is not significantly released for a period of up to at least one-half-life (6.7 days). We also demonstrate that this agent can be conjugated with an interleukin-13 peptide that is designed to target an overexpressed receptor in glioblastoma multiforme tumors. This nanoparticle delivery platform provides flexibility for a wide range of radiotherapeutic and radiodiagnostic multimodal applications.",

author = "M. Shultz and J. Duchamp and Wilson, \{John D.\} and C. Shu and Jiechao Ge and J. Zhang and H. Gibson and Helen Fillmore and J. Hirsch and H. Dorn and P. Fatouros",

year = "2010",

doi = "10.1021/ja9093617",

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journal = "Journal of the American Chemical Society",

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Shultz, M, Duchamp, J, Wilson, JD, Shu, C, Ge, J, Zhang, J, Gibson, H, Fillmore, H, Hirsch, J, Dorn, H & Fatouros, P 2010, 'Encapsulation of a radiolabeled cluster inside a fullerene cage, 177LuxLu(3−x)N@C80: an interleukin-13-conjugated radiolabeled metallofullerene platform', Journal of the American Chemical Society, vol. 132, no. 14, pp. 4980-4981. https://doi.org/10.1021/ja9093617

TY - JOUR

T1 - Encapsulation of a radiolabeled cluster inside a fullerene cage, 177LuxLu(3−x)N@C80: an interleukin-13-conjugated radiolabeled metallofullerene platform

AU - Shultz, M.

AU - Duchamp, J.

AU - Wilson, John D.

AU - Shu, C.

AU - Ge, Jiechao

AU - Zhang, J.

AU - Gibson, H.

AU - Fillmore, Helen

AU - Hirsch, J.

AU - Dorn, H.

AU - Fatouros, P.

PY - 2010

Y1 - 2010

N2 - In this communication, we describe the successful encapsulation of 177Lu into the endohedral metallofullerene 177LuxLu3−xN@C80 (x = 1−3) starting with 177LuCl3 in a modified quartz Kräschmer−Huffman electric generator. We demonstrate that the 177Lu (β-emitter) in this fullerene cage is not significantly released for a period of up to at least one-half-life (6.7 days). We also demonstrate that this agent can be conjugated with an interleukin-13 peptide that is designed to target an overexpressed receptor in glioblastoma multiforme tumors. This nanoparticle delivery platform provides flexibility for a wide range of radiotherapeutic and radiodiagnostic multimodal applications.

AB - In this communication, we describe the successful encapsulation of 177Lu into the endohedral metallofullerene 177LuxLu3−xN@C80 (x = 1−3) starting with 177LuCl3 in a modified quartz Kräschmer−Huffman electric generator. We demonstrate that the 177Lu (β-emitter) in this fullerene cage is not significantly released for a period of up to at least one-half-life (6.7 days). We also demonstrate that this agent can be conjugated with an interleukin-13 peptide that is designed to target an overexpressed receptor in glioblastoma multiforme tumors. This nanoparticle delivery platform provides flexibility for a wide range of radiotherapeutic and radiodiagnostic multimodal applications.

U2 - 10.1021/ja9093617

DO - 10.1021/ja9093617

M3 - Article

SN - 0002-7863

VL - 132

SP - 4980

EP - 4981

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 14

ER -

Encapsulation of a radiolabeled cluster inside a fullerene cage, 177LuxLu(3−x)N@C80: an interleukin-13-conjugated radiolabeled metallofullerene platform

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