Entonox as an analgesic agent during panretinal photocoagulation

H. L. Cook*, Richard Babington Newsom, E. Mensah, M. Saeed, D. James, T. J. ffytche

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background/aims: Panretinal photocoagulation (PRP) reduces the risk of visual loss in proliferative diabetic retinopathy but some patients cannot tolerate PRP because of pain. Inhaled Entonox was evaluated as an analgesic during PRP.
Methods: A randomised, crossover, double masked pilot study was performed. Patients inhaled either air or Entonox and half the PRP was applied. The treatment was completed with the alternate inhaled gas. Patients graded pain experienced during both stages of the treatment using a visual analogue scale. Pain scores were compared using a paired t test.
Results: 20 patients participated. Mean pain scores from the Entonox and air treatments were 2.94 (SD 2.73) versus 3.73 (SD 3.20) respectively (p<0.03).
Conclusion: Entonox can be used as a safe and effective analgesic agent during PRP treatment.
Original languageEnglish
Pages (from-to)1107-1108
JournalBritish Journal of Ophthalmology
Issue number10
Publication statusPublished - 1 Oct 2002


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