Epigenome-modifying tools in asthma

Peter O. Brook, Mark M. Perry, Ian M. Adcock, Andrew L. Durham

Research output: Contribution to journalArticlepeer-review

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Abstract

Asthma is a chronic disease which causes recurrent breathlessness affecting 300 million people worldwide of whom 250,000 die annually. The epigenome is a set of heritable modifications and tags that affect the genome without changing the intrinsic DNA sequence. These marks include DNA methylation, modifications to histone proteins around which DNA is wrapped and expression of noncoding RNA. Alterations in all of these processes have been reported in patients with asthma. In some cases these differences are linked to disease severity and susceptibility and may account for the limited value of genetic studies in asthma. Animal models of asthma suggest that epigenetic modifications and processes are linked to asthma and may be tractable targets for therapeutic intervention.
Original languageEnglish
Pages (from-to)1017-1032
Number of pages16
JournalEpigenomics
Volume7
Issue number6
DOIs
Publication statusPublished - 1 Sep 2015

Keywords

  • asthma
  • DNA methylation
  • epigenetics
  • histone modification
  • miRNA
  • T cell
  • therapeutics

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