Epigenome-modifying tools in asthma

Peter O. Brook; Mark M. Perry; Ian M. Adcock; Andrew L. Durham

doi:10.2217/epi.15.53

Epigenome-modifying tools in asthma

Peter O. Brook, Mark M. Perry, Ian M. Adcock, Andrew L. Durham

Research output: Contribution to journal › Article › peer-review

101 Downloads (Pure)

Abstract

Asthma is a chronic disease which causes recurrent breathlessness affecting 300 million people worldwide of whom 250,000 die annually. The epigenome is a set of heritable modifications and tags that affect the genome without changing the intrinsic DNA sequence. These marks include DNA methylation, modifications to histone proteins around which DNA is wrapped and expression of noncoding RNA. Alterations in all of these processes have been reported in patients with asthma. In some cases these differences are linked to disease severity and susceptibility and may account for the limited value of genetic studies in asthma. Animal models of asthma suggest that epigenetic modifications and processes are linked to asthma and may be tractable targets for therapeutic intervention.

Original language	English
Pages (from-to)	1017-1032
Number of pages	16
Journal	Epigenomics
Volume	7
Issue number	6
DOIs	https://doi.org/10.2217/epi.15.53
Publication status	Published - 1 Sept 2015

Keywords

asthma
DNA methylation
epigenetics
histone modification
miRNA
T cell
therapeutics

Access to Document

10.2217/epi.15.53

Epigenome-modifying tools in asthmaFinal published version, 911 KBLicence: CC BY

http://www.futuremedicine.com/doi/10.2217/epi.15.53

Cite this

@article{23896edc2a584711a081d7757262f1ba,

title = "Epigenome-modifying tools in asthma",

abstract = "Asthma is a chronic disease which causes recurrent breathlessness affecting 300 million people worldwide of whom 250,000 die annually. The epigenome is a set of heritable modifications and tags that affect the genome without changing the intrinsic DNA sequence. These marks include DNA methylation, modifications to histone proteins around which DNA is wrapped and expression of noncoding RNA. Alterations in all of these processes have been reported in patients with asthma. In some cases these differences are linked to disease severity and susceptibility and may account for the limited value of genetic studies in asthma. Animal models of asthma suggest that epigenetic modifications and processes are linked to asthma and may be tractable targets for therapeutic intervention.",

keywords = "asthma, DNA methylation, epigenetics, histone modification, miRNA, T cell, therapeutics",

author = "Brook, {Peter O.} and Perry, {Mark M.} and Adcock, {Ian M.} and Durham, {Andrew L.}",

year = "2015",

month = sep,

day = "1",

doi = "10.2217/epi.15.53",

language = "English",

volume = "7",

pages = "1017--1032",

journal = "Epigenomics",

issn = "1750-1911",

publisher = "Future Medicine Ltd.",

number = "6",

}

TY - JOUR

T1 - Epigenome-modifying tools in asthma

AU - Brook, Peter O.

AU - Perry, Mark M.

AU - Adcock, Ian M.

AU - Durham, Andrew L.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Asthma is a chronic disease which causes recurrent breathlessness affecting 300 million people worldwide of whom 250,000 die annually. The epigenome is a set of heritable modifications and tags that affect the genome without changing the intrinsic DNA sequence. These marks include DNA methylation, modifications to histone proteins around which DNA is wrapped and expression of noncoding RNA. Alterations in all of these processes have been reported in patients with asthma. In some cases these differences are linked to disease severity and susceptibility and may account for the limited value of genetic studies in asthma. Animal models of asthma suggest that epigenetic modifications and processes are linked to asthma and may be tractable targets for therapeutic intervention.

AB - Asthma is a chronic disease which causes recurrent breathlessness affecting 300 million people worldwide of whom 250,000 die annually. The epigenome is a set of heritable modifications and tags that affect the genome without changing the intrinsic DNA sequence. These marks include DNA methylation, modifications to histone proteins around which DNA is wrapped and expression of noncoding RNA. Alterations in all of these processes have been reported in patients with asthma. In some cases these differences are linked to disease severity and susceptibility and may account for the limited value of genetic studies in asthma. Animal models of asthma suggest that epigenetic modifications and processes are linked to asthma and may be tractable targets for therapeutic intervention.

KW - asthma

KW - DNA methylation

KW - epigenetics

KW - histone modification

KW - miRNA

KW - T cell

KW - therapeutics

U2 - 10.2217/epi.15.53

DO - 10.2217/epi.15.53

M3 - Article

SN - 1750-1911

VL - 7

SP - 1017

EP - 1032

JO - Epigenomics

JF - Epigenomics

IS - 6

ER -

Epigenome-modifying tools in asthma

Abstract

Keywords

Access to Document

Fingerprint

Cite this