Evaluation of lung recruitment maneuvers in acute respiratory distress syndrome using computer simulation

Anup Das, Oana Cole, Marc Chikhani, Wenfei Wang, Tayyba Ali, Mainul Haque, Declan G. Bates, Jonathan G. Hardman

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Abstract

Direct comparison of the relative efficacy of different recruitment maneuvers (RMs) for patients with acute respiratory distress syndrome (ARDS) via clinical trials is difficult, due to the heterogeneity of patient populations and disease states, as well as a variety of practical issues. There is also significant uncertainty regarding the minimum values of positive end-expiratory pressure (PEEP) required to ensure maintenance of effective lung recruitment using RMs. We used patient-specific computational simulation to analyze how three different RMs act to improve physiological responses, and investigate how different levels of PEEP contribute to maintaining effective lung recruitment.
Original languageEnglish
Article number8
Number of pages15
JournalCritical Care
Volume19
Issue number1
DOIs
Publication statusPublished - 12 Jan 2015

Keywords

  • RCUK
  • EPSRC
  • EP/F057016/2
  • EP/F057059/1
  • EP/1036680/2
  • MRC
  • G1002017
  • MR/K019783

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