Expression of the chondroitin sulphate proteoglycan, NG2, in paediatric brain tumors

Samantha Higgins; Anna J. Boltheus; Laura Donovan; Harutomo Hasegawa; Lawrence  Doey; Safa Al Sarraj; Keyoumars Ashkan; Federico Roncaroli; Helen Fillmore; Geoff Pilkington

Expression of the chondroitin sulphate proteoglycan, NG2, in paediatric brain tumors

Samantha Higgins, Anna J. Boltheus, Laura Donovan, Harutomo Hasegawa, Lawrence Doey, Safa Al Sarraj, Keyoumars Ashkan, Federico Roncaroli, Helen Fillmore, Geoff Pilkington

Institute of Life Sciences and Healthcare

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Abstract

Background/Aim: While neuron-glia 2 (NG2) is well-characterized in the developing brain and in adult high-grade gliomas, little is known about NG2 expression in paediatric brain tumors. Here, NG2 expression was examined in a range of paediatric brain tumors.

Materials and Methods: A retrospective immunohistopathological analysis of 57 paediatric brain tumor biopsies of various tumor types was carried out. Paediatric cell lines, including two medulloblastomas and one dysembryoplastic neuroepithelial tumor, in addition to one adult high-grade glioma, were also assessed for NG2 expression.

Results: NG2-positive staining was seen in all dysembryoplastic neuroepithelial tumors (DNETs) examined; however, only two of the fourteen medulloblastomas examined were NG2-positive. Compared to adult glioma, there was a lack of NG2 staining in the vasculature of paediatric brain tumors.

Conclusion: NG2 expression in paediatric brain tumors differs depending upon type and, unlike adult glioma, includes expression on lower-grade tumors.

Original language	English
Pages (from-to)	6919-6924
Number of pages	6
Journal	Anticancer Research
Volume	34
Issue number	12
Publication status	Published - 1 Dec 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

brain tumors
NG2
paediatric

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http://ar.iiarjournals.org/content/34/12/6919.short

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title = "Expression of the chondroitin sulphate proteoglycan, NG2, in paediatric brain tumors",

abstract = "Background/Aim: While neuron-glia 2 (NG2) is well-characterized in the developing brain and in adult high-grade gliomas, little is known about NG2 expression in paediatric brain tumors. Here, NG2 expression was examined in a range of paediatric brain tumors. Materials and Methods: A retrospective immunohistopathological analysis of 57 paediatric brain tumor biopsies of various tumor types was carried out. Paediatric cell lines, including two medulloblastomas and one dysembryoplastic neuroepithelial tumor, in addition to one adult high-grade glioma, were also assessed for NG2 expression. Results: NG2-positive staining was seen in all dysembryoplastic neuroepithelial tumors (DNETs) examined; however, only two of the fourteen medulloblastomas examined were NG2-positive. Compared to adult glioma, there was a lack of NG2 staining in the vasculature of paediatric brain tumors. Conclusion: NG2 expression in paediatric brain tumors differs depending upon type and, unlike adult glioma, includes expression on lower-grade tumors.",

keywords = "brain tumors, NG2, paediatric",

author = "Samantha Higgins and Boltheus, \{Anna J.\} and Laura Donovan and Harutomo Hasegawa and Lawrence Doey and Sarraj, \{Safa Al\} and Keyoumars Ashkan and Federico Roncaroli and Helen Fillmore and Geoff Pilkington",

year = "2014",

month = dec,

day = "1",

language = "English",

volume = "34",

pages = "6919--6924",

journal = "Anticancer Research",

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TY - JOUR

T1 - Expression of the chondroitin sulphate proteoglycan, NG2, in paediatric brain tumors

AU - Higgins, Samantha

AU - Boltheus, Anna J.

AU - Donovan, Laura

AU - Hasegawa, Harutomo

AU - Doey, Lawrence

AU - Sarraj, Safa Al

AU - Ashkan, Keyoumars

AU - Roncaroli, Federico

AU - Fillmore, Helen

AU - Pilkington, Geoff

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Background/Aim: While neuron-glia 2 (NG2) is well-characterized in the developing brain and in adult high-grade gliomas, little is known about NG2 expression in paediatric brain tumors. Here, NG2 expression was examined in a range of paediatric brain tumors. Materials and Methods: A retrospective immunohistopathological analysis of 57 paediatric brain tumor biopsies of various tumor types was carried out. Paediatric cell lines, including two medulloblastomas and one dysembryoplastic neuroepithelial tumor, in addition to one adult high-grade glioma, were also assessed for NG2 expression. Results: NG2-positive staining was seen in all dysembryoplastic neuroepithelial tumors (DNETs) examined; however, only two of the fourteen medulloblastomas examined were NG2-positive. Compared to adult glioma, there was a lack of NG2 staining in the vasculature of paediatric brain tumors. Conclusion: NG2 expression in paediatric brain tumors differs depending upon type and, unlike adult glioma, includes expression on lower-grade tumors.

AB - Background/Aim: While neuron-glia 2 (NG2) is well-characterized in the developing brain and in adult high-grade gliomas, little is known about NG2 expression in paediatric brain tumors. Here, NG2 expression was examined in a range of paediatric brain tumors. Materials and Methods: A retrospective immunohistopathological analysis of 57 paediatric brain tumor biopsies of various tumor types was carried out. Paediatric cell lines, including two medulloblastomas and one dysembryoplastic neuroepithelial tumor, in addition to one adult high-grade glioma, were also assessed for NG2 expression. Results: NG2-positive staining was seen in all dysembryoplastic neuroepithelial tumors (DNETs) examined; however, only two of the fourteen medulloblastomas examined were NG2-positive. Compared to adult glioma, there was a lack of NG2 staining in the vasculature of paediatric brain tumors. Conclusion: NG2 expression in paediatric brain tumors differs depending upon type and, unlike adult glioma, includes expression on lower-grade tumors.

KW - brain tumors

KW - NG2

KW - paediatric

M3 - Article

SN - 0250-7005

VL - 34

SP - 6919

EP - 6924

JO - Anticancer Research

JF - Anticancer Research

IS - 12

ER -

Expression of the chondroitin sulphate proteoglycan, NG2, in paediatric brain tumors

Abstract

UN SDGs

Keywords

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