Extrinsic versus intrinsic cues in avian paraxial mesoderm patterning and differentiation

Ingo Bothe, Mohi U. Ahmed, Farrah L. Winterbottom, Gudrun von Scheven, Susanne Dietrich

Research output: Contribution to journalArticlepeer-review


Somitic and head mesoderm contribute to cartilage and bone and deliver the entire skeletal musculature. Studies on avian somite patterning and cell differentiation led to the view that these processes depend solely on cues from surrounding tissues. However, evidence is accumulating that some developmental decisions depend on information within the somitic tissue itself. Moreover, recent studies established that head and somitic mesoderm, though delivering the same tissue types, are set up to follow their own, distinct developmental programmes. With a particular focus on the chicken embryo, we review the current understanding of how extrinsic signalling, operating in a framework of intrinsically regulated constraints, controls paraxial mesoderm patterning and cell differentiation.
Original languageEnglish
Pages (from-to)2397-2409
JournalDevelopmental Dynamics
Issue number9
Early online date24 Jul 2007
Publication statusPublished - Sept 2007
Externally publishedYes


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