Forces for folding

Colyn Crane-Robinson

Research output: Contribution to journalComment/debatepeer-review

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Understanding the nature of the forces driving the folding of proteins, nucleic acids and the formation of their complexes absolutely requires thermodynamic data, in addition to structural information. In practical terms, this means the use of super-sensitive scanning and titration calorimeters for experimental determination of the heats (enthalpies) characterising these processes. Peter Privalov was both an experimental thermodynamicist and a calorimeter designer/manufacturer who followed and propagated this credo. The sum total of his many publications, every one of which addresses a fundamental question, is his lasting epitaph.
Original languageEnglish
Pages (from-to)126-128
Number of pages3
JournalActa Naturae
Issue number2
Publication statusPublished - 1 Apr 2021


  • thermodynamics
  • calorimeters
  • enthalpy
  • proetin folding
  • hydration


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