Free radical pathology in chronic arterial disease

Jill J. F. Belch; Mridula Chopra; Stephen Hutchison; Ross Lorimer; Roger D. Sturrock; Charles D. Forbes; W. Ewen Smith

doi:10.1016/0891-5849(89)90082-8

Free radical pathology in chronic arterial disease

Jill J. F. Belch^*, Mridula Chopra, Stephen Hutchison, Ross Lorimer, Roger D. Sturrock, Charles D. Forbes, W. Ewen Smith

^*Corresponding author for this work

School of Pharmacy & Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The generation of toxic oxygen metabolites is more usually associated with inflammation. However, pathological free radical reactions can cause tissue damage by adversely affecting prostacyclin (PGI₂) synthesis allowing initiation of coagulation. We have assessed changes in the red cell defence to toxic oxygen metabolite generation, viz measurement of glutathione concentration (GSH) and superoxide dismutase activity (SOD). GSH and SOD were measured in 20 patients with peripheral arterial disease, 22 patients with vasculitis, and 11 patients with angina, and compared to 17 matched controls. The 53 subjects with arterial disease and significantly lower SOD levels: in contrast GSH levels were significantly higher. Extracellularly plasma thiol levels (PSH) were low and caeruloplasmin (Cp) levels were high. We suggest that free radical pathology exists not only in inflammatory vascular disease but also in atherosclerosis.

Original language	English
Pages (from-to)	375-378
Number of pages	4
Journal	Free Radical Biology and Medicine
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/0891-5849(89)90082-8
Publication status	Published - 1 Aug 1989

Keywords

Arterial disease
Free radicals
Toxic oxygen metabolites

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10.1016/0891-5849(89)90082-8

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title = "Free radical pathology in chronic arterial disease",

abstract = "The generation of toxic oxygen metabolites is more usually associated with inflammation. However, pathological free radical reactions can cause tissue damage by adversely affecting prostacyclin (PGI2) synthesis allowing initiation of coagulation. We have assessed changes in the red cell defence to toxic oxygen metabolite generation, viz measurement of glutathione concentration (GSH) and superoxide dismutase activity (SOD). GSH and SOD were measured in 20 patients with peripheral arterial disease, 22 patients with vasculitis, and 11 patients with angina, and compared to 17 matched controls. The 53 subjects with arterial disease and significantly lower SOD levels: in contrast GSH levels were significantly higher. Extracellularly plasma thiol levels (PSH) were low and caeruloplasmin (Cp) levels were high. We suggest that free radical pathology exists not only in inflammatory vascular disease but also in atherosclerosis.",

keywords = "Arterial disease, Free radicals, Toxic oxygen metabolites",

author = "Belch, {Jill J. F.} and Mridula Chopra and Stephen Hutchison and Ross Lorimer and Sturrock, {Roger D.} and Forbes, {Charles D.} and {Ewen Smith}, W.",

note = "Funding Information: Acknowledgement--This work was supported by grants from the Royal College of Physicians, London, and from the British Heart Foundation (BHF86/72).",

year = "1989",

month = aug,

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doi = "10.1016/0891-5849(89)90082-8",

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T1 - Free radical pathology in chronic arterial disease

AU - Belch, Jill J. F.

AU - Chopra, Mridula

AU - Hutchison, Stephen

AU - Lorimer, Ross

AU - Sturrock, Roger D.

AU - Forbes, Charles D.

AU - Ewen Smith, W.

N1 - Funding Information: Acknowledgement--This work was supported by grants from the Royal College of Physicians, London, and from the British Heart Foundation (BHF86/72).

PY - 1989/8/1

Y1 - 1989/8/1

N2 - The generation of toxic oxygen metabolites is more usually associated with inflammation. However, pathological free radical reactions can cause tissue damage by adversely affecting prostacyclin (PGI2) synthesis allowing initiation of coagulation. We have assessed changes in the red cell defence to toxic oxygen metabolite generation, viz measurement of glutathione concentration (GSH) and superoxide dismutase activity (SOD). GSH and SOD were measured in 20 patients with peripheral arterial disease, 22 patients with vasculitis, and 11 patients with angina, and compared to 17 matched controls. The 53 subjects with arterial disease and significantly lower SOD levels: in contrast GSH levels were significantly higher. Extracellularly plasma thiol levels (PSH) were low and caeruloplasmin (Cp) levels were high. We suggest that free radical pathology exists not only in inflammatory vascular disease but also in atherosclerosis.

AB - The generation of toxic oxygen metabolites is more usually associated with inflammation. However, pathological free radical reactions can cause tissue damage by adversely affecting prostacyclin (PGI2) synthesis allowing initiation of coagulation. We have assessed changes in the red cell defence to toxic oxygen metabolite generation, viz measurement of glutathione concentration (GSH) and superoxide dismutase activity (SOD). GSH and SOD were measured in 20 patients with peripheral arterial disease, 22 patients with vasculitis, and 11 patients with angina, and compared to 17 matched controls. The 53 subjects with arterial disease and significantly lower SOD levels: in contrast GSH levels were significantly higher. Extracellularly plasma thiol levels (PSH) were low and caeruloplasmin (Cp) levels were high. We suggest that free radical pathology exists not only in inflammatory vascular disease but also in atherosclerosis.

KW - Arterial disease

KW - Free radicals

KW - Toxic oxygen metabolites

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U2 - 10.1016/0891-5849(89)90082-8

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VL - 6

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EP - 378

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

IS - 4

ER -

Free radical pathology in chronic arterial disease

Abstract

Keywords

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