Free radical scavenging: A potentially beneficial action of thiol-containing angiotensin converting enzyme inhibitors

M. Chopra, J. McMurray, J. Stewart, H. J. Dargie, W. E. Smith

Research output: Contribution to journalReview articlepeer-review

Abstract

Free radical (FR) scavenging may be a therapeutically useful adjunctive property of angiotensin converting enzyme (ACE) inhibitors. In this study we have shown that SH-containing ACE inhibitors (captopril, epicaptopril, zofenopril) are potent FR scavengers at a concentration of 4 x 10-5 M whereas non-SH ACE inhibitors (enalaprilat, quinaprilat and perindoprilat) have no FR-scavenging activity at this concentration. Furthermore, the SH-containing agents preferentially scavenged general radicals rather than superoxide radicals, i.e. suggesting that these drugs would be effective in quenching the culprit FR in ischaemia/reperfusion injury.

Original languageEnglish
Pages (from-to)1184-1185
Number of pages2
JournalBiochemical Society Transactions
Volume18
Issue number6
DOIs
Publication statusPublished - 1 Dec 1990

Keywords

  • angiotensin converting enzyme
  • ACE
  • free radical
  • FR

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