The Salton Sea, the largest lake of California, is now facing problems due to its massive fish and bird mortality. Haque and Chattopadhyay1 have proposed and analyzed an eco-epidemiological model on Salton Sea. The present article deals with the global stability analysis of the positive interior equilibrium of that eco-epidemiological model. We use the geometric approach to the global stability analysis for ordinary differential equations which is based on the use of higher-order generalization of Bendixson's criterion. Our conclusion is that for persistence of the pelican (main predator) populations in Salton Sea, harvesting of tilapia (specially infected) populations is an utmost important factor.