Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy

Qian An; G. Burke; M. Dainton; C. Harrison; H. Kempski; Z. Konn; A. Stewart; M. Taj; D. Webb; J. Strefford; M. Martineau

doi:10.1038/leu.2009.238

Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy

Qian An
, G. Burke
, M. Dainton
, C. Harrison
, H. Kempski
, Z. Konn
, A. Stewart
, M. Taj
, D. Webb
, J. Strefford
, M. Martineau

Research output: Contribution to journal › Article › peer-review

Abstract

There are many different mechanisms by which the promiscuous MLL gene, with a diversity of partners, can be converted into an oncogene. These include translocations, duplications, insertions and deletions all of which have been linked to HOX gene deregulation as the mediator of haematological malignancy.

Original language	English
Pages (from-to)	649-652
Number of pages	4
Journal	Leukaemia
Volume	24
DOIs	https://doi.org/10.1038/leu.2009.238
Publication status	Published - 2009

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10.1038/leu.2009.238

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title = "Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy",

abstract = "There are many different mechanisms by which the promiscuous MLL gene, with a diversity of partners, can be converted into an oncogene. These include translocations, duplications, insertions and deletions all of which have been linked to HOX gene deregulation as the mediator of haematological malignancy.",

author = "Qian An and G. Burke and M. Dainton and C. Harrison and H. Kempski and Z. Konn and A. Stewart and M. Taj and D. Webb and J. Strefford and M. Martineau",

year = "2009",

doi = "10.1038/leu.2009.238",

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journal = "Leukaemia",

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AU - An, Qian

AU - Burke, G.

AU - Dainton, M.

AU - Harrison, C.

AU - Kempski, H.

AU - Konn, Z.

AU - Stewart, A.

AU - Taj, M.

AU - Webb, D.

AU - Strefford, J.

AU - Martineau, M.

PY - 2009

Y1 - 2009

N2 - There are many different mechanisms by which the promiscuous MLL gene, with a diversity of partners, can be converted into an oncogene. These include translocations, duplications, insertions and deletions all of which have been linked to HOX gene deregulation as the mediator of haematological malignancy.

AB - There are many different mechanisms by which the promiscuous MLL gene, with a diversity of partners, can be converted into an oncogene. These include translocations, duplications, insertions and deletions all of which have been linked to HOX gene deregulation as the mediator of haematological malignancy.

U2 - 10.1038/leu.2009.238

DO - 10.1038/leu.2009.238

M3 - Article

SN - 0887-6924

VL - 24

SP - 649

EP - 652

JO - Leukaemia

JF - Leukaemia

ER -

Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy

Abstract

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