TY - JOUR
T1 - Amburana cearensis: pharmacological and neuroprotective effects of its compounds
AU - Silva, Juliana Helena Castro E.
AU - Ferreira, Rafael Short
AU - Pereira, Erica Patricia
AU - Braga-de-Souza, Suzana
AU - Almeida, Monique Marylin Alves de
AU - Santos, Cleonice Creusa dos
AU - Butt, Arthur Morgan
AU - Caiazzo, Elisabetta
AU - Capasso, Raffaele
AU - Silva, Victor Diogenes Amaral da
AU - Costa, Silvia Lima
PY - 2020/7/27
Y1 - 2020/7/27
N2 - Amburana cearensis A. C. Smith is an endemic tree from Northeastern Brazil used in folk medicine as teas, decocts and syrups for the treatment of various respiratory and inflammatory diseases, since therapeutic properties have been attributed to compounds from its stem bark and seeds. Numerous pharmacological properties of semi-purified extracts and isolated compounds from A. cearensis have been described in several biological systems, ranging from antimicrobial to anti-inflammatory effects. Some of these activities are attributed to coumarins and phenolic compounds, the major compounds present in A. cearensis seed extracts. Multiple lines of research demonstrate these compounds reduce oxidative stress, inflammation and neuronal death induced by glutamate excitotoxicity, events central to most neuropathologies, including Alzheimer’s disease (AD) and Parkinson’s Disease (PD). This review focuses on the botanical aspects, folk medicine use, biological effects and pharmacological activities of A. cearensis compounds and their potential as novel non-toxic drugs for the treatment of neurodegenerative diseases.
AB - Amburana cearensis A. C. Smith is an endemic tree from Northeastern Brazil used in folk medicine as teas, decocts and syrups for the treatment of various respiratory and inflammatory diseases, since therapeutic properties have been attributed to compounds from its stem bark and seeds. Numerous pharmacological properties of semi-purified extracts and isolated compounds from A. cearensis have been described in several biological systems, ranging from antimicrobial to anti-inflammatory effects. Some of these activities are attributed to coumarins and phenolic compounds, the major compounds present in A. cearensis seed extracts. Multiple lines of research demonstrate these compounds reduce oxidative stress, inflammation and neuronal death induced by glutamate excitotoxicity, events central to most neuropathologies, including Alzheimer’s disease (AD) and Parkinson’s Disease (PD). This review focuses on the botanical aspects, folk medicine use, biological effects and pharmacological activities of A. cearensis compounds and their potential as novel non-toxic drugs for the treatment of neurodegenerative diseases.
KW - Amburana cearensis
KW - pharmacological activities
KW - central nervous system
KW - RCUK
KW - BBSRC
KW - BB/M029379/1
UR - https://www.mdpi.com/1420-3049/25/15/3394
U2 - 10.3390/molecules25153394
DO - 10.3390/molecules25153394
M3 - Literature review
SN - 1420-3049
VL - 25
JO - Molecules
JF - Molecules
IS - 15
M1 - 3394
ER -