Impaction grafting with a bone-graft substitute in a sheep model of revision hip replacement

M Coathup, N Smith, C Kingsley, T Buckland, R Dattani, G P Ascroft, G Blunn

    Research output: Contribution to journalArticlepeer-review

    Abstract

    An experimental sheep model was used for impaction allografting of 12 hemiarthroplasty femoral components placed into two equal-sized groups. In group 1, a 50:50 mixture of ApaPore hydroxyapatite bone-graft substitute and allograft was used. In group 2, ApaPore and allograft were mixed in a 90:10 ratio. Both groups were killed at six months. Ground reaction force results demonstrated no significant differences (p > 0.05) between the two groups at 8, 16 and 24 weeks post-operatively, and all animals remained active. The mean bone turnover rates were significantly greater in group 1, at 0.00206 mm/day, compared to group 2 at 0.0013 mm/day (p < 0.05). The results for the area of new bone formation demonstrated no significant differences (p > 0.05) between the two groups. No significant differences were found between the two groups in thickness of the cement mantle (p > 0.05) and percentage ApaPore-bone contact (p > 0.05). The results of this animal study demonstrated that a mixture of ApaPore allograft in a 90:10 ratio was comparable to using a 50:50 mixture.

    Original languageEnglish
    Pages (from-to)246-53
    Number of pages8
    JournalJournal of Bone and Joint Surgery - British Volume
    Volume90
    Issue number2
    DOIs
    Publication statusPublished - Feb 2008

    Keywords

    • Animals
    • Anti-Bacterial Agents
    • Arthroplasty, Replacement, Hip
    • Biomarkers
    • Biomechanical Phenomena
    • Bone Substitutes
    • Bone Transplantation
    • Female
    • Femur
    • Microscopy, Electron, Scanning
    • Osteogenesis
    • Prosthesis Design
    • Sheep
    • Tetracycline

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