Abstract
An experimental sheep model was used for impaction allografting of 12 hemiarthroplasty femoral components placed into two equal-sized groups. In group 1, a 50:50 mixture of ApaPore hydroxyapatite bone-graft substitute and allograft was used. In group 2, ApaPore and allograft were mixed in a 90:10 ratio. Both groups were killed at six months. Ground reaction force results demonstrated no significant differences (p > 0.05) between the two groups at 8, 16 and 24 weeks post-operatively, and all animals remained active. The mean bone turnover rates were significantly greater in group 1, at 0.00206 mm/day, compared to group 2 at 0.0013 mm/day (p < 0.05). The results for the area of new bone formation demonstrated no significant differences (p > 0.05) between the two groups. No significant differences were found between the two groups in thickness of the cement mantle (p > 0.05) and percentage ApaPore-bone contact (p > 0.05). The results of this animal study demonstrated that a mixture of ApaPore allograft in a 90:10 ratio was comparable to using a 50:50 mixture.
Original language | English |
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Pages (from-to) | 246-53 |
Number of pages | 8 |
Journal | Journal of Bone and Joint Surgery - British Volume |
Volume | 90 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2008 |
Keywords
- Animals
- Anti-Bacterial Agents
- Arthroplasty, Replacement, Hip
- Biomarkers
- Biomechanical Phenomena
- Bone Substitutes
- Bone Transplantation
- Female
- Femur
- Microscopy, Electron, Scanning
- Osteogenesis
- Prosthesis Design
- Sheep
- Tetracycline