Imprinted M6p/Igf2 receptor is mutated in rat liver tumors

J. J. Mills, J. G. Falls, A. T. De Souza, R. L. Jirtle*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We have previously shown that inactivation of mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a common early event in both human liver and breast carcinogenesis. The M6p/Igf2r is imprinted in mice while expression is biallelic in most humans. In this investigation the M6p/Igf2r gene is shown to also be imprinted in the liver of Fischer 344, Lewis and Brown Norway rats. In addition, we have identified mutations in the expressed allele of the M6p/Igf2r in 40% of diethylnitrosamine-initiated rat liver tumors. These results provide further evidence that the M6P/IGF2R functions as a liver tumor suppressor gene. They also suggest that mice and rats would be more sensitive than humans to those hepatocarcinogens in which the M6p/Igf2r is mechanistically involved in transformation since one rather than two alleles would need to be inactivated.

Original languageEnglish
Pages (from-to)2797-2802
Number of pages6
Issue number21
Publication statusPublished - 28 May 1998


  • Genomic imprinting
  • Liver cancer
  • M6p/Igf2r
  • Tumor suppressor


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