TY - JOUR
T1 - Inhibition of phosphatidylinositol phosphodiesterase activity in skeletal muscle by metal ions and drugs which block neuromuscular transmission
AU - Shute, Janis K.
AU - Smith, Margaret E.
PY - 1985/7/15
Y1 - 1985/7/15
N2 - The calcium-dependent phosphatidylinositol phosphodiesterase activity of skeletal muscle cytosol was determined. The enzyme was inhibited by Zn2+, Cu2+ and Pb2+ ions but Mg2+ and Mn2+ were without effect. The antimalarial drugs chloroquine and quinine and the aminoglycoside antibiotics gentamicin and neomycin all of which, like Zn2+, have been shown to block neuromuscular transmission, also inhibited the enzyme.
AB - The calcium-dependent phosphatidylinositol phosphodiesterase activity of skeletal muscle cytosol was determined. The enzyme was inhibited by Zn2+, Cu2+ and Pb2+ ions but Mg2+ and Mn2+ were without effect. The antimalarial drugs chloroquine and quinine and the aminoglycoside antibiotics gentamicin and neomycin all of which, like Zn2+, have been shown to block neuromuscular transmission, also inhibited the enzyme.
UR - http://www.scopus.com/inward/record.url?scp=0021824467&partnerID=8YFLogxK
UR - https://www.sciencedirect.com/journal/biochemical-pharmacology/vol/34/issue/14
U2 - 10.1016/0006-2952(85)90528-3
DO - 10.1016/0006-2952(85)90528-3
M3 - Article
C2 - 2990487
AN - SCOPUS:0021824467
SN - 0006-2952
VL - 34
SP - 2471
EP - 2475
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
IS - 14
ER -