TY - JOUR
T1 - Intersex related gene expression profiles in clams Scrobicularia plana
T2 - molecular markers and environmental application
AU - Ciocan, Corina M.
AU - Cubero-Leon, Elena
AU - Langston, William J.
AU - Pope, Nick
AU - Cornelius, Keith
AU - Hill, E. M.
AU - Alvarez-Munoz, Diana
AU - Indiveri, Paolo
AU - Lerebours, Adelaide
AU - Minier, Christophe
AU - Rotchell, Jeanette M.
PY - 2015/6
Y1 - 2015/6
N2 - Intersex, the appearance of female characteristics in male gonads, has been identified in several aquatic species. It is a widespread phenomenon in populations of the bivalve, Scrobicularia plana, from the southwest coast of the U.K. Genes previously identified as differentially expressed (ferritin, testicular haploid expressed gene, THEG, proliferating cell nuclear antigen, PCNA; receptor activated protein kinase C, RACK; cytochrome B, CYB; and cytochrome c oxidase 1, COX1) in intersex clams relative to normal male clams, were selected for characterisation and an environmental survey of the Channel region. Transcripts were significantly differentially expressed at sites with varying intersex incidence and contaminant burdens. Significant correlations between specific gene expressions, key contaminants and sampling locations have been identified, though no single gene was associated with intersex incidence. The results highlight the difficulty in understanding the intersex phenomenon in molluscs where there is still a lack of knowledge on the control of normal reproduction.
AB - Intersex, the appearance of female characteristics in male gonads, has been identified in several aquatic species. It is a widespread phenomenon in populations of the bivalve, Scrobicularia plana, from the southwest coast of the U.K. Genes previously identified as differentially expressed (ferritin, testicular haploid expressed gene, THEG, proliferating cell nuclear antigen, PCNA; receptor activated protein kinase C, RACK; cytochrome B, CYB; and cytochrome c oxidase 1, COX1) in intersex clams relative to normal male clams, were selected for characterisation and an environmental survey of the Channel region. Transcripts were significantly differentially expressed at sites with varying intersex incidence and contaminant burdens. Significant correlations between specific gene expressions, key contaminants and sampling locations have been identified, though no single gene was associated with intersex incidence. The results highlight the difficulty in understanding the intersex phenomenon in molluscs where there is still a lack of knowledge on the control of normal reproduction.
U2 - 10.1016/j.marpolbul.2015.02.019
DO - 10.1016/j.marpolbul.2015.02.019
M3 - Article
SN - 0025-326X
VL - 95
SP - 610
EP - 617
JO - Marine Pollution Bulletin
JF - Marine Pollution Bulletin
IS - 2
ER -