Intrinsic, hox-dependent cues determine the fate of skeletal muscle precursors

L. Alvares, Frank Schubert, C. Thorpe, R. Mootoosamy, L. Cheng, G. Parkyn, A. Lumsden, Susanne Dietrich

    Research output: Contribution to journalArticlepeer-review

    Abstract

    It is generally held that vertebrate muscle precursors depend totally on environmental cues for their development. We show that instead, somites are predisposed toward a particular myogenic program. This predisposition depends on the somite's axial identity: when flank somites are transformed into limb-level somites, either by shifting somitic boundaries with FGF8 or by overexpressing posterior Hox genes, they readily activate the program typical for migratory limb muscle precursors. The intrinsic control over myogenic programs can only be overridden by FGF4 signals provided by the apical ectodermal ridge of a developing limb.
    Original languageEnglish
    Pages (from-to)379-390
    Number of pages12
    JournalDevelopmental Cell
    Volume5
    Issue number3
    DOIs
    Publication statusPublished - 2003

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