Investigation of spatio-temporal dependencies in neuronal functional connectivity

Matthew C. Spencer, Dimitris Xydas, Julia H. Downes, Mark W. Hammond, Victor Becerra, Kevin Warwick, Benjamin J. Whalley, Slawomir J. Nasuto

    Research output: Chapter in Book/Report/Conference proceedingConference contribution


    Determining how the functional connectivity in cortical cultures on multi-electrode arrays develops over time can provide new and helpful insight into how cognitive pathways form. This study uses both data- and model-driven approaches to determine what dependencies are present in and between functional connectivity networks derived from bursts of extra-cellularly recorded activity. Two models were used to capture the dynamics of individual functional connections and their consistencies were verified using surrogate data. By comparing network-wide properties between model generated networks and functional networks from data, complex interdependencies were revealed. This indicates the persistent co-activation of neuronal pathways, as can be found in whole brain structures and further supports the use of cortical cultures as a consistent model for neuronal studies.
    Original languageEnglish
    Title of host publication2010 IEEE 9th International Conference on Cybernetic Intelligent Systems (CIS)
    Place of PublicationPiscataway
    PublisherInstitute of Electrical and Electronics Engineers Inc.
    ISBN (Electronic)9781424490240
    ISBN (Print)9781424490233
    Publication statusPublished - 2010


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