Investigation of spatio-temporal dependencies in neuronal functional connectivity

Matthew C. Spencer, Dimitris Xydas, Julia H. Downes, Mark W. Hammond, Victor Becerra, Kevin Warwick, Benjamin J. Whalley, Slawomir J. Nasuto

    Research output: Chapter in Book/Report/Conference proceedingConference contribution


    Determining how the functional connectivity in cortical cultures on multi-electrode arrays develops over time can provide new and helpful insight into how cognitive pathways form. This study uses both data- and model-driven approaches to determine what dependencies are present in and between functional connectivity networks derived from bursts of extra-cellularly recorded activity. Two models were used to capture the dynamics of individual functional connections and their consistencies were verified using surrogate data. By comparing network-wide properties between model generated networks and functional networks from data, complex interdependencies were revealed. This indicates the persistent co-activation of neuronal pathways, as can be found in whole brain structures and further supports the use of cortical cultures as a consistent model for neuronal studies.
    Original languageEnglish
    Title of host publication2010 IEEE 9th International Conference on Cybernetic Intelligent Systems (CIS)
    Place of PublicationPiscataway
    ISBN (Electronic)9781424490240
    ISBN (Print)9781424490233
    Publication statusPublished - 2010


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