Wireless Sensor Network (WSN) is vulnerable to interference from other wireless technologies such as WLAN, Bluetooth and cordless phone due to its low transmission power, data rate and bandwidth. Energy Detection (ED) is one of the available sensing technique available in Clear Channel Assessment (CCA) that is used to reduce packet collision due to interference and hidden terminal problem. To the authors' knowledge, there are numerous studies that have been conducted to investigate the coexistence of WSN with other wireless technologies and methods to overcome interference have been proposed. However, only a few studies involves ED. Thus, this study aims to investigate the impact of multimedia streaming on ED and packet loss in the home environment. A series of experimental tests were conducted in actual environment in order to study the interference phenomenon of ED and packet loss. This investigation will provide some valuable insight regarding ED in real-home environment and findings from this study will served as a baseline study or reference for future studies.