Ion-dependency of the streptococcal deoxyribonuclease “streptodornase”, an active constituent of the medicament Varidase®

I. Locke; Brian Carpenter

doi:10.1016/S0141-0229(02)00125-4

Ion-dependency of the streptococcal deoxyribonuclease “streptodornase”, an active constituent of the medicament Varidase®

I. Locke, Brian Carpenter

Research output: Contribution to journal › Article › peer-review

Abstract

The activity of streptodornase, a deoxyribonuclease active protein component of the medicament Varidase® has been shown to be dependant on the presence and concentration of certain cation species. Anion species appear to have little effect on streptodornase activity. In particular, the divalent cations magnesium and calcium are essential for optimum activity whilst sodium ions are inhibitory. The overall effect of ion concentration on streptodornase activity is a result of a complex interplay between the various ion species. These effects and conditions are described and a possible explanation for the observed interplay is offered.

Original language	English
Pages (from-to)	482-489
Number of pages	8
Journal	Enzyme and Microbial Technology
Volume	31
Issue number	4
DOIs	https://doi.org/10.1016/S0141-0229(02)00125-4
Publication status	Published - 2 Sept 2002

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title = "Ion-dependency of the streptococcal deoxyribonuclease “streptodornase”, an active constituent of the medicament Varidase{\textregistered}",

abstract = "The activity of streptodornase, a deoxyribonuclease active protein component of the medicament Varidase{\textregistered} has been shown to be dependant on the presence and concentration of certain cation species. Anion species appear to have little effect on streptodornase activity. In particular, the divalent cations magnesium and calcium are essential for optimum activity whilst sodium ions are inhibitory. The overall effect of ion concentration on streptodornase activity is a result of a complex interplay between the various ion species. These effects and conditions are described and a possible explanation for the observed interplay is offered.",

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AU - Carpenter, Brian

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N2 - The activity of streptodornase, a deoxyribonuclease active protein component of the medicament Varidase® has been shown to be dependant on the presence and concentration of certain cation species. Anion species appear to have little effect on streptodornase activity. In particular, the divalent cations magnesium and calcium are essential for optimum activity whilst sodium ions are inhibitory. The overall effect of ion concentration on streptodornase activity is a result of a complex interplay between the various ion species. These effects and conditions are described and a possible explanation for the observed interplay is offered.

AB - The activity of streptodornase, a deoxyribonuclease active protein component of the medicament Varidase® has been shown to be dependant on the presence and concentration of certain cation species. Anion species appear to have little effect on streptodornase activity. In particular, the divalent cations magnesium and calcium are essential for optimum activity whilst sodium ions are inhibitory. The overall effect of ion concentration on streptodornase activity is a result of a complex interplay between the various ion species. These effects and conditions are described and a possible explanation for the observed interplay is offered.

U2 - 10.1016/S0141-0229(02)00125-4

DO - 10.1016/S0141-0229(02)00125-4

M3 - Article

SN - 0141-0229

VL - 31

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EP - 489

JO - Enzyme and Microbial Technology

JF - Enzyme and Microbial Technology

IS - 4

ER -

Ion-dependency of the streptococcal deoxyribonuclease “streptodornase”, an active constituent of the medicament Varidase®

Abstract

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