Kidney beam-A cost-effective digital intervention to improve mental health

Sharlene A. Greenwood; Juliet Briggs; Christy Walklin; Emmanuel Mangahis; Hannah M.L. Young; Ellen M. Castle; Roseanne E. Billany; Elham Asgari; Sunil Bhandari; Nicolette Bishop; Kate Bramham; James O. Burton; Jackie Campbell; Joseph Chilcot; Nicola Cooper; Vashist Deelchand; Matthew P.M. Graham-Brown; Lynda Haggis; Alexander Hamilton; Mark Jesky; Philip A. Kalra; Pelagia Koufaki; Kieran McCafferty; Andrew C. Nixon; Helen Noble; Zoe L. Saynor; Maarten W. Taal; James Tollitt; David C. Wheeler; Thomas J. Wilkinson; Hannah Worboys; Jamie Macdonald

doi:10.1016/j.ekir.2024.08.030

Kidney beam-A cost-effective digital intervention to improve mental health

Sharlene A. Greenwood
, Juliet Briggs
, Christy Walklin
, Emmanuel Mangahis
, Hannah M.L. Young
, Ellen M. Castle
, Roseanne E. Billany
, Elham Asgari
, Sunil Bhandari
, Nicolette Bishop
, Kate Bramham
, James O. Burton
, Jackie Campbell
, Joseph Chilcot
, Nicola Cooper
, Vashist Deelchand
, Matthew P.M. Graham-Brown
, Lynda Haggis
, Alexander Hamilton
, Mark Jesky

Philip A. Kalra, Pelagia Koufaki, Kieran McCafferty, Andrew C. Nixon, Helen Noble, Zoe L. Saynor, Maarten W. Taal, James Tollitt, David C. Wheeler, Thomas J. Wilkinson, Hannah Worboys, Jamie Macdonald

University of Southampton

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: There is inequity in the provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention (DHI) in CKD.

Methods: In a single-blind, 11 center, randomized controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity DHI or a waitlist control. This study assessed the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6-months, and cost-effectiveness of the intervention.

Results: At 6-months, there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 [95% confidence interval, CI: 4.4–7.5] arbitrary units [AU], P < 0.0001), and a 93% and 98% chance of the intervention being cost-effective at a willingness-to-pay threshold of £20,000 and £30,000 per quality-adjusted life year gained.

Conclusion: The Kidney BEAM physical activity DHI is a clinically valuable and cost-effective means to improve mental health-related quality of life (HRQoL) in people with CKD (trial registration no. NCT04872933).

Original language	English
Pages (from-to)	3204-3217
Journal	Kidney International Reports
Volume	9
Issue number	11
DOIs	https://doi.org/10.1016/j.ekir.2024.08.030
Publication status	Published - 1 Nov 2024
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1016/j.ekir.2024.08.030

Kidney Beam-A Cost-EffectiveFinal published version, 523 KBLicence: CC BY

https://eprints.soton.ac.uk/493875/

Cite this

Greenwood, S. A., Briggs, J., Walklin, C., Mangahis, E., Young, H. M. L., Castle, E. M., Billany, R. E., Asgari, E., Bhandari, S., Bishop, N., Bramham, K., Burton, J. O., Campbell, J., Chilcot, J., Cooper, N., Deelchand, V., Graham-Brown, M. P. M., Haggis, L., Hamilton, A., ... Macdonald, J. (2024). Kidney beam-A cost-effective digital intervention to improve mental health. Kidney International Reports, 9(11), 3204-3217. https://doi.org/10.1016/j.ekir.2024.08.030

@article{0ee171c8efc64243b7cadc88a8531032,

title = "Kidney beam-A cost-effective digital intervention to improve mental health",

abstract = "Introduction: There is inequity in the provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention (DHI) in CKD. Methods: In a single-blind, 11 center, randomized controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity DHI or a waitlist control. This study assessed the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6-months, and cost-effectiveness of the intervention. Results: At 6-months, there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 [95\% confidence interval, CI: 4.4–7.5] arbitrary units [AU], P < 0.0001), and a 93\% and 98\% chance of the intervention being cost-effective at a willingness-to-pay threshold of £20,000 and £30,000 per quality-adjusted life year gained. Conclusion: The Kidney BEAM physical activity DHI is a clinically valuable and cost-effective means to improve mental health-related quality of life (HRQoL) in people with CKD (trial registration no. NCT04872933).",

author = "Greenwood, \{Sharlene A.\} and Juliet Briggs and Christy Walklin and Emmanuel Mangahis and Young, \{Hannah M.L.\} and Castle, \{Ellen M.\} and Billany, \{Roseanne E.\} and Elham Asgari and Sunil Bhandari and Nicolette Bishop and Kate Bramham and Burton, \{James O.\} and Jackie Campbell and Joseph Chilcot and Nicola Cooper and Vashist Deelchand and Graham-Brown, \{Matthew P.M.\} and Lynda Haggis and Alexander Hamilton and Mark Jesky and Kalra, \{Philip A.\} and Pelagia Koufaki and Kieran McCafferty and Nixon, \{Andrew C.\} and Helen Noble and Saynor, \{Zoe L.\} and Taal, \{Maarten W.\} and James Tollitt and Wheeler, \{David C.\} and Wilkinson, \{Thomas J.\} and Hannah Worboys and Jamie Macdonald",

year = "2024",

month = nov,

day = "1",

doi = "10.1016/j.ekir.2024.08.030",

language = "English",

volume = "9",

pages = "3204--3217",

journal = "Kidney International Reports",

issn = "2468-0249",

publisher = "Elsevier Inc.",

number = "11",

}

Greenwood, SA, Briggs, J, Walklin, C, Mangahis, E, Young, HML, Castle, EM, Billany, RE, Asgari, E, Bhandari, S, Bishop, N, Bramham, K, Burton, JO, Campbell, J, Chilcot, J, Cooper, N, Deelchand, V, Graham-Brown, MPM, Haggis, L, Hamilton, A, Jesky, M, Kalra, PA, Koufaki, P, McCafferty, K, Nixon, AC, Noble, H, Saynor, ZL, Taal, MW, Tollitt, J, Wheeler, DC, Wilkinson, TJ, Worboys, H & Macdonald, J 2024, 'Kidney beam-A cost-effective digital intervention to improve mental health', Kidney International Reports, vol. 9, no. 11, pp. 3204-3217. https://doi.org/10.1016/j.ekir.2024.08.030

TY - JOUR

T1 - Kidney beam-A cost-effective digital intervention to improve mental health

AU - Greenwood, Sharlene A.

AU - Briggs, Juliet

AU - Walklin, Christy

AU - Mangahis, Emmanuel

AU - Young, Hannah M.L.

AU - Castle, Ellen M.

AU - Billany, Roseanne E.

AU - Asgari, Elham

AU - Bhandari, Sunil

AU - Bishop, Nicolette

AU - Bramham, Kate

AU - Burton, James O.

AU - Campbell, Jackie

AU - Chilcot, Joseph

AU - Cooper, Nicola

AU - Deelchand, Vashist

AU - Graham-Brown, Matthew P.M.

AU - Haggis, Lynda

AU - Hamilton, Alexander

AU - Jesky, Mark

AU - Kalra, Philip A.

AU - Koufaki, Pelagia

AU - McCafferty, Kieran

AU - Nixon, Andrew C.

AU - Noble, Helen

AU - Saynor, Zoe L.

AU - Taal, Maarten W.

AU - Tollitt, James

AU - Wheeler, David C.

AU - Wilkinson, Thomas J.

AU - Worboys, Hannah

AU - Macdonald, Jamie

PY - 2024/11/1

Y1 - 2024/11/1

N2 - Introduction: There is inequity in the provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention (DHI) in CKD. Methods: In a single-blind, 11 center, randomized controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity DHI or a waitlist control. This study assessed the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6-months, and cost-effectiveness of the intervention. Results: At 6-months, there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 [95% confidence interval, CI: 4.4–7.5] arbitrary units [AU], P < 0.0001), and a 93% and 98% chance of the intervention being cost-effective at a willingness-to-pay threshold of £20,000 and £30,000 per quality-adjusted life year gained. Conclusion: The Kidney BEAM physical activity DHI is a clinically valuable and cost-effective means to improve mental health-related quality of life (HRQoL) in people with CKD (trial registration no. NCT04872933).

AB - Introduction: There is inequity in the provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention (DHI) in CKD. Methods: In a single-blind, 11 center, randomized controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity DHI or a waitlist control. This study assessed the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6-months, and cost-effectiveness of the intervention. Results: At 6-months, there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 [95% confidence interval, CI: 4.4–7.5] arbitrary units [AU], P < 0.0001), and a 93% and 98% chance of the intervention being cost-effective at a willingness-to-pay threshold of £20,000 and £30,000 per quality-adjusted life year gained. Conclusion: The Kidney BEAM physical activity DHI is a clinically valuable and cost-effective means to improve mental health-related quality of life (HRQoL) in people with CKD (trial registration no. NCT04872933).

U2 - 10.1016/j.ekir.2024.08.030

DO - 10.1016/j.ekir.2024.08.030

M3 - Article

SN - 2468-0249

VL - 9

SP - 3204

EP - 3217

JO - Kidney International Reports

JF - Kidney International Reports

IS - 11

ER -

Kidney beam-A cost-effective digital intervention to improve mental health

Abstract

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