Linker histones: history and current perspectives

C. Crane-Robinson

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Although the overall structure of the fifth histone (linker histone, H1) is understood, its location on the nucleosome is only partially defined. Whilst it is clear that H1 helps condense the chromatin fibre, precisely how this is achieved remains to be determined. H1 is not a general gene repressor in that although it must be displaced from transcription start sites for activity to occur, there is only partial loss along the body of genes. How the deposition and removal of H1 occurs in particular need of further study. Linker histones are highly abundant nuclear proteins about which we know too little. This article is part of a Special Issue entitled: Histone H1, edited by Dr. Albert Jordan.
Original languageEnglish
Pages (from-to)431-435
JournalBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
Issue number3
Early online date14 Oct 2015
Publication statusPublished - Mar 2016


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