Liposome formulations of o-carborane for the boron neutron capture therapy of cancer

Temidayo Olusanya; Gianpiero Calabrese; Dimitrios G. Fatouros; John Tsibouklis; James Smith

doi:10.1016/j.bpc.2019.01.003

Liposome formulations of o-carborane for the boron neutron capture therapy of cancer

Temidayo Olusanya, Gianpiero Calabrese, Dimitrios G. Fatouros, John Tsibouklis, James Smith

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Abstract

Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80 – 100 nm) of dipalmitoyl-phosphatidylcholine (DPPC) or 1,2-distearol-sn-glycerol-3-phosphocholine (DSPC). Preliminary pharmaceutical characterisation experiments have demonstrated the integrity of both DPPC and DSPC liposomal membranes in serum and in PBS and also indicate that these o-carborane-loaded liposomes are candidate carrier vehicles for further evaluation with a view to exploitation in BNCT.

Original language	English
Pages (from-to)	25-33
Journal	Biophysical Chemistry
Volume	247
Early online date	15 Feb 2019
DOIs	https://doi.org/10.1016/j.bpc.2019.01.003
Publication status	Published - Apr 2019

Keywords

liposomes
Cancer
BNCT
Nanoparticles

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bpc.2019.01.003

2019_BiophysChem_postprintAccepted author manuscript (Post-print), 1.04 MBLicence: CC BY-NC-ND

Formulation and preliminary evaluation of delivery vehicles for the boron neutron capture therapy of cancer
Olusanya, T. (Author), Tsibouklis, J. (Supervisor) & Smith, J. (Supervisor), Feb 2015
Student thesis: Doctoral Thesis

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Formulation and preliminary evaluation of delivery vehicles for the boron neutron capture therapy of cancer
Smith, J. (CoI) & Tsibouklis, J. (PI)
1/09/09 → 20/03/15
Project: Research

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title = "Liposome formulations of o-carborane for the boron neutron capture therapy of cancer",

abstract = "Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80 – 100 nm) of dipalmitoyl-phosphatidylcholine (DPPC) or 1,2-distearol-sn-glycerol-3-phosphocholine (DSPC). Preliminary pharmaceutical characterisation experiments have demonstrated the integrity of both DPPC and DSPC liposomal membranes in serum and in PBS and also indicate that these o-carborane-loaded liposomes are candidate carrier vehicles for further evaluation with a view to exploitation in BNCT.",

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author = "Temidayo Olusanya and Gianpiero Calabrese and Fatouros, {Dimitrios G.} and John Tsibouklis and James Smith",

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AU - Olusanya, Temidayo

AU - Calabrese, Gianpiero

AU - Fatouros, Dimitrios G.

AU - Tsibouklis, John

AU - Smith, James

N1 - 24 month embargo

PY - 2019/4

Y1 - 2019/4

N2 - Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80 – 100 nm) of dipalmitoyl-phosphatidylcholine (DPPC) or 1,2-distearol-sn-glycerol-3-phosphocholine (DSPC). Preliminary pharmaceutical characterisation experiments have demonstrated the integrity of both DPPC and DSPC liposomal membranes in serum and in PBS and also indicate that these o-carborane-loaded liposomes are candidate carrier vehicles for further evaluation with a view to exploitation in BNCT.

AB - Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80 – 100 nm) of dipalmitoyl-phosphatidylcholine (DPPC) or 1,2-distearol-sn-glycerol-3-phosphocholine (DSPC). Preliminary pharmaceutical characterisation experiments have demonstrated the integrity of both DPPC and DSPC liposomal membranes in serum and in PBS and also indicate that these o-carborane-loaded liposomes are candidate carrier vehicles for further evaluation with a view to exploitation in BNCT.

KW - liposomes

KW - Cancer

KW - BNCT

KW - Nanoparticles

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DO - 10.1016/j.bpc.2019.01.003

M3 - Article

SN - 0301-4622

VL - 247

SP - 25

EP - 33

JO - Biophysical Chemistry

JF - Biophysical Chemistry

ER -

Liposome formulations of o-carborane for the boron neutron capture therapy of cancer

Abstract

Keywords

UN SDGs

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Formulation and preliminary evaluation of delivery vehicles for the boron neutron capture therapy of cancer

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Formulation and preliminary evaluation of delivery vehicles for the boron neutron capture therapy of cancer

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