Liposome formulations of o-carborane for the boron neutron capture therapy of cancer

Temidayo Olusanya, Gianpiero Calabrese, Dimitrios G. Fatouros, John Tsibouklis, James Smith

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Abstract

Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80 – 100 nm) of dipalmitoyl-phosphatidylcholine (DPPC) or 1,2-distearol-sn-glycerol-3-phosphocholine (DSPC). Preliminary pharmaceutical characterisation experiments have demonstrated the integrity of both DPPC and DSPC liposomal membranes in serum and in PBS and also indicate that these o-carborane-loaded liposomes are candidate carrier vehicles for further evaluation with a view to exploitation in BNCT.
Original languageEnglish
Pages (from-to)25-33
JournalBiophysical Chemistry
Volume247
Early online date15 Feb 2019
DOIs
Publication statusPublished - Apr 2019

Keywords

  • liposomes
  • Cancer
  • BNCT
  • Nanoparticles

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