Marine bacterial inhibitors from the sponge-derived fungus Aspergillus sp

Yaming Zhou, Abdessamad Debbab, Victor Wray, WenHan Lin, Barbara Schulz, Rozenn Trepos, Claire Pile, Claire Hellio, Peter Proksch, Amal H. Aly

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Abstract

Chromatographic separation of a crude extract obtained from the fungus Aspergillus sp., isolated from the Mediterranean sponge Tethya aurantium, yielded a new tryptophan derived alkaloid, 3-((1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxoindolin- 3-yl)methyl)-1-methyl-3,4-dihydrobenzo[e][1,4]diazepine-2,5-dione (1) and a new meroterpenoid, austalide R (2), together with three known compounds (3-5). The structures of the new compounds were unambiguously elucidated on the basis of extensive one and two-dimensional NMR (1H, 13C, COSY, HMBC, and ROESY) and mass spectral analysis. Interestingly, the compounds exhibited antibacterial activity when tested against a panel of marine bacteria, with 1 selectively inhibiting Vibrio species and 2 showing a broad spectrum of activity. In contrast, no significant activity was observed against terrestrial bacterial strains and the murine cancer cell line
L5178Y.
Original languageEnglish
Pages (from-to)2789-2792
JournalTetrahedron Letters
Volume55
Issue number17
Early online date13 Mar 2014
DOIs
Publication statusPublished - 23 Apr 2014

Keywords

  • Aspergillus
  • Marine natural products
  • Sponge-derived fungi
  • Tethya aurantium

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