Mechano-Growth Factor: an important cog or a loose screw in the repair machinery?

B. Zabtocka, P. Goldspink, G. Goldspink, Darek Gorecki

Research output: Contribution to journalArticlepeer-review


Insulin-like growth factor I (IGF-1) is an important peptide synthesized in response to growth hormone stimulation. Alternative promoters and an elaborate alternative splicing regulated in a tissue- and developmentally-specific manner result in the production of several distinct isoforms of IGF-1 [reviewed in Gorecki et al. (2007); Matheny et al. (2010)]. The predominant form, IGF-1Ea is a circulating factor produced in the liver while IGF-1Eb and IGF-1Ec (Mechano-Growth Factor, MGF) are expressed in specific tissues in response to different, often pathological stimuli and appear to have some specific functions in these different tissues [reviewed in Aberg et al. (2006); Gorecki et al. (2007); Matheny et al. (2010)].
Original languageEnglish
Pages (from-to)131
Number of pages1
JournalFrontiers in Experimental Endocrinology
Publication statusPublished - Nov 2012


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