Metabotropic glutamate receptors protect oligodendrocytes from acute ischemia in the mouse optic nerve

Arthur M. Butt, Ilaria Vanzulli, Maria Papanikolaou, Irene Chacon De La Rocha, Virginia E. Hawkins

Research output: Contribution to journalArticlepeer-review

147 Downloads (Pure)


Studies by Bruce Ransom and colleagues have made a major contribution to show that white matter is susceptible to ischemia/hypoxia. White matter contains axons and the glia that support them, notably myelinating oligodendrocytes, which are highly vulnerable to ischemic-hypoxic damage. Previous studies have shown that metabotropic GluRs (mGluRs) are cytoprotective for oligodendrocyte precursor cells and immature oligodendrocytes, but their potential role in adult white matter was unresolved. Here, we report that group 1 mGluR1/5 and group 2 mGluR3 subunits are expressed in optic nerves from mice aged postnatal day (P)8–12 and P30–35. We demonstrate that activation of group 1 mGluR protects oligodendrocytes against oxygen-glucose deprivation (OGD) in developing and young adult optic nerves. In contrast, group 2 mGluR are shown to be protective for oligodendrocytes against OGD in postnatal but not young adult optic nerves. The cytoprotective effect of group 1 mGluR requires activation of PKC, whilst group 2 mGluR are dependent on negatively regulating adenylyl cyclase and cAMP. Our results identify a role for mGluR in limiting injury of oligodendrocytes in developing and young adult white matter, which may be useful for protecting oligodendrocytes in neuropathologies involving excitoxicity and ischemia/hypoxia.
Original languageEnglish
JournalNeurochemical Research
Early online date1 Apr 2017
Publication statusEarly online - 1 Apr 2017


  • RCUK
  • Oligodendrocyte
  • Ischemia
  • Hypoxia
  • White matter
  • Optic nerve
  • Glutamate
  • Metabotropic glutamate receptor


Dive into the research topics of 'Metabotropic glutamate receptors protect oligodendrocytes from acute ischemia in the mouse optic nerve'. Together they form a unique fingerprint.

Cite this