Microchannel neural interface manufacture by stacking silicone and metal foil laminae

Henry T. Lancashire; Anne Vanhoestenberghe; Catherine J. Pendegrass; Yazan Al Ajam; Elliot Magee; Nick Donaldson; Gordon W. Blunn

doi:10.1088/1741-2560/13/3/034001

Microchannel neural interface manufacture by stacking silicone and metal foil laminae

Henry T. Lancashire, Anne Vanhoestenberghe, Catherine J. Pendegrass, Yazan Al Ajam, Elliot Magee, Nick Donaldson, Gordon W. Blunn

Research output: Contribution to journal › Article › peer-review

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Abstract

Objective - Microchannel neural interfaces (MNIs) overcome problems with recording from peripheral nerves by amplifying signals independent of node of Ranvier position. Selective recording and stimulation using an MNI requires good insulation between microchannels and a high electrode density. We propose that stacking microchannel laminae will improve selectivity over single layer MNI designs due to the increase in electrode number and an improvement in microchannel sealing.

Approach - This paper describes a manufacturing method for creating MNIs which overcomes limitations on electrode connectivity and microchannel sealing. Laser cut silicone-metal foil laminae were stacked using plasma bonding to create an array of microchannels containing tripolar electrodes. Electrodes were DC etched and electrode impedance and cyclic voltammetry were tested.

Main Results - MNIs with 100 μm and 200 μm diameter microchannels were manufactured. High electrode density MNIs are achievable with electrodes present in every microchannel. Electrode impedances of 27.2 ± 19.8 kΩ at 1 kHz were achieved. Following two months of implantation in Lewis rat sciatic nerve, micro-fascicles were observed regenerating through the MNI microchannels.

Significance - Selective MNIs with the peripheral nervous system may allow upper limb amputees to control prostheses intuitively.

Original language	English
Article number	034001
Journal	Journal of Neural Engineering
Volume	13
Issue number	3
DOIs	https://doi.org/10.1088/1741-2560/13/3/034001
Publication status	Published - 22 Mar 2016

Keywords

Animals
Brain-Computer Interfaces
Electric Impedance
Electrodes
Electrodes, Implanted
Equipment Failure Analysis
Interferometry
Male
Metals
Neurons
Peripheral Nerves
Prosthesis Design
Rats
Rats, Inbred Lew
Silicones
Research Support, Non-U.S. Gov't
RCUK
EPSRC
EP/G036675/1

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Microchannel neural interface manufactureFinal published version, 1.5 MBLicence: CC BY

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title = "Microchannel neural interface manufacture by stacking silicone and metal foil laminae",

abstract = "Objective - Microchannel neural interfaces (MNIs) overcome problems with recording from peripheral nerves by amplifying signals independent of node of Ranvier position. Selective recording and stimulation using an MNI requires good insulation between microchannels and a high electrode density. We propose that stacking microchannel laminae will improve selectivity over single layer MNI designs due to the increase in electrode number and an improvement in microchannel sealing.Approach - This paper describes a manufacturing method for creating MNIs which overcomes limitations on electrode connectivity and microchannel sealing. Laser cut silicone-metal foil laminae were stacked using plasma bonding to create an array of microchannels containing tripolar electrodes. Electrodes were DC etched and electrode impedance and cyclic voltammetry were tested.Main Results - MNIs with 100 μm and 200 μm diameter microchannels were manufactured. High electrode density MNIs are achievable with electrodes present in every microchannel. Electrode impedances of 27.2 ± 19.8 kΩ at 1 kHz were achieved. Following two months of implantation in Lewis rat sciatic nerve, micro-fascicles were observed regenerating through the MNI microchannels.Significance - Selective MNIs with the peripheral nervous system may allow upper limb amputees to control prostheses intuitively.",

keywords = "Animals, Brain-Computer Interfaces, Electric Impedance, Electrodes, Electrodes, Implanted, Equipment Failure Analysis, Interferometry, Male, Metals, Neurons, Peripheral Nerves, Prosthesis Design, Rats, Rats, Inbred Lew, Silicones, Research Support, Non-U.S. Gov't, RCUK, EPSRC, EP/G036675/1",

author = "Lancashire, {Henry T.} and Anne Vanhoestenberghe and Pendegrass, {Catherine J.} and Ajam, {Yazan Al} and Elliot Magee and Nick Donaldson and Blunn, {Gordon W.}",

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doi = "10.1088/1741-2560/13/3/034001",

language = "English",

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journal = "Journal of Neural Engineering",

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AU - Lancashire, Henry T.

AU - Vanhoestenberghe, Anne

AU - Pendegrass, Catherine J.

AU - Ajam, Yazan Al

AU - Magee, Elliot

AU - Donaldson, Nick

AU - Blunn, Gordon W.

PY - 2016/3/22

Y1 - 2016/3/22

N2 - Objective - Microchannel neural interfaces (MNIs) overcome problems with recording from peripheral nerves by amplifying signals independent of node of Ranvier position. Selective recording and stimulation using an MNI requires good insulation between microchannels and a high electrode density. We propose that stacking microchannel laminae will improve selectivity over single layer MNI designs due to the increase in electrode number and an improvement in microchannel sealing.Approach - This paper describes a manufacturing method for creating MNIs which overcomes limitations on electrode connectivity and microchannel sealing. Laser cut silicone-metal foil laminae were stacked using plasma bonding to create an array of microchannels containing tripolar electrodes. Electrodes were DC etched and electrode impedance and cyclic voltammetry were tested.Main Results - MNIs with 100 μm and 200 μm diameter microchannels were manufactured. High electrode density MNIs are achievable with electrodes present in every microchannel. Electrode impedances of 27.2 ± 19.8 kΩ at 1 kHz were achieved. Following two months of implantation in Lewis rat sciatic nerve, micro-fascicles were observed regenerating through the MNI microchannels.Significance - Selective MNIs with the peripheral nervous system may allow upper limb amputees to control prostheses intuitively.

AB - Objective - Microchannel neural interfaces (MNIs) overcome problems with recording from peripheral nerves by amplifying signals independent of node of Ranvier position. Selective recording and stimulation using an MNI requires good insulation between microchannels and a high electrode density. We propose that stacking microchannel laminae will improve selectivity over single layer MNI designs due to the increase in electrode number and an improvement in microchannel sealing.Approach - This paper describes a manufacturing method for creating MNIs which overcomes limitations on electrode connectivity and microchannel sealing. Laser cut silicone-metal foil laminae were stacked using plasma bonding to create an array of microchannels containing tripolar electrodes. Electrodes were DC etched and electrode impedance and cyclic voltammetry were tested.Main Results - MNIs with 100 μm and 200 μm diameter microchannels were manufactured. High electrode density MNIs are achievable with electrodes present in every microchannel. Electrode impedances of 27.2 ± 19.8 kΩ at 1 kHz were achieved. Following two months of implantation in Lewis rat sciatic nerve, micro-fascicles were observed regenerating through the MNI microchannels.Significance - Selective MNIs with the peripheral nervous system may allow upper limb amputees to control prostheses intuitively.

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Microchannel neural interface manufacture by stacking silicone and metal foil laminae

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