MISSION ABC: Transforming respiratory care through one-stop multidisciplinary clinics - an observational study

Mission ABC Collaborators, Thomas Llewelyn Jones, Mark Amos, Thomas Brown, Anoop J. Chauhan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Objectives: The Modern Innovative Solutions to Improve Outcomes in Asthma, Breathlessness and Chronic Obstructive Pulmonary Disease (COPD) (MABC) service aimed to enhance disease management for chronic respiratory conditions through specialist multidisciplinary clinics, predominantly in the community. This study assesses the outcomes of these clinics. 

Design: This study used a prospective, longitudinal, participatory action research approach. 

Setting: The study was conducted in primary care practices across Hampshire, UK. 

Participants: Adults aged 16 years and above with poorly controlled asthma or COPD, as well as those with undifferentiated breathlessness not under specialist care, were included. 

Interventions: Participants received care through the multidisciplinary, specialist-led MABC clinics. 

Primary and secondary outcome measures: Primary outcomes included disease activity, quality of life and healthcare utilisation. Secondary outcomes encompassed clinic attendance, diagnostic changes, patient activation, participant and healthcare professional experiences and cost-effectiveness. 

Results: A total of 441 participants from 11 general practitioner practices were recruited. Ninety-six per cent of participants would recommend MABC clinics. MABC assessments led to diagnosis changes for 64 (17%) participants with asthma and COPD and treatment adjustments for 252 participants (57%). Exacerbations decreased significantly from 236 to 30 after attending the clinics (p<0.005), with a mean reduction of 0.53 exacerbation events per participant. Reductions were also seen in unscheduled and out-of-hours primary care attendance, emergency department visits and hospital admissions (all p<0.005). Cost savings from reduced exacerbations and healthcare utilisation offset increased medication costs and clinic expenses. 

Conclusions: Specialist-supported multidisciplinary teams in MABC clinics improved diagnosis accuracy and adherence to guidelines. High patient satisfaction, disease control improvements and reduced exacerbations resulted in decreased unscheduled healthcare use and cost savings. Trial registration number NCT03096509.

Original languageEnglish
Article numbere078947
Number of pages9
JournalBMJ Open
Issue number1
Publication statusPublished - 8 Jan 2024


  • asthma
  • patient participation
  • primary health care
  • pulmonary disease, chronic obstructive

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