Modulating autophagy as a therapeutic strategy for the treatment of paediatric high grade glioma

Alison Howarth, Patricia A. Madureira, George Lockwood, Lisa C. D. Storer, Richard Grundy, Ruman Rahman, Geoffrey J. Pilkington, Richard Hill

Research output: Contribution to journalReview articlepeer-review

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Abstract

Paediatric high grade glioma (pHGG) represent a therapeutically challenging group of tumours. Despite decades of research there has been a minimal improvement in treatment and the clinical prognosis remains poor. Autophagy, a highly conserved process for recycling metabolic substrates is upregulated in pHGG, promoting tumour progression and evading cell death. There is significant cross talk between autophagy and a plethora of critical cellular pathways, many of which are dysregulated in pHGG. The following article will discuss our current understanding of autophagy signalling in pHGG and the potential modulation of this network as a therapeutic target.

Original languageEnglish
Number of pages19
JournalBrain Pathology
Early online date13 May 2019
DOIs
Publication statusEarly online - 13 May 2019

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