Modulating autophagy as a therapeutic strategy for the treatment of paediatric high grade glioma

Alison Howarth; Patricia A. Madureira; George Lockwood; Lisa C. D. Storer; Richard Grundy; Ruman Rahman; Geoffrey J. Pilkington; Richard Hill

doi:10.1111/bpa.12729

Modulating autophagy as a therapeutic strategy for the treatment of paediatric high grade glioma

Alison Howarth, Patricia A. Madureira, George Lockwood, Lisa C. D. Storer, Richard Grundy, Ruman Rahman, Geoffrey J. Pilkington, Richard Hill

Institute of Life Sciences and Healthcare

Research output: Contribution to journal › Review article › peer-review

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Abstract

Paediatric high grade glioma (pHGG) represent a therapeutically challenging group of tumours. Despite decades of research there has been a minimal improvement in treatment and the clinical prognosis remains poor. Autophagy, a highly conserved process for recycling metabolic substrates is upregulated in pHGG, promoting tumour progression and evading cell death. There is significant cross talk between autophagy and a plethora of critical cellular pathways, many of which are dysregulated in pHGG. The following article will discuss our current understanding of autophagy signalling in pHGG and the potential modulation of this network as a therapeutic target.

Original language	English
Number of pages	19
Journal	Brain Pathology
Early online date	13 May 2019
DOIs	https://doi.org/10.1111/bpa.12729
Publication status	Early online - 13 May 2019

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Howarth_et_al-2019-Brain_Pathology
This is the peer reviewed version of the following article: Howarth, A. , Madureira, P. A., Lockwood, G. , Storer, L. C., Grundy, R. , Rahman, R. , Pilkington, G. J. and Hill, R. (2019), Modulating Autophagy as a Therapeutic Strategy for the Treatment of Paediatric High Grade Glioma. Brain Pathol., which has been published in final form at doi:10.1111/bpa.12729. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Accepted author manuscript (Post-print), 1.67 MB

https://onlinelibrary.wiley.com/doi/full/10.1111/bpa.12729

Cite this

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abstract = "Paediatric high grade glioma (pHGG) represent a therapeutically challenging group of tumours. Despite decades of research there has been a minimal improvement in treatment and the clinical prognosis remains poor. Autophagy, a highly conserved process for recycling metabolic substrates is upregulated in pHGG, promoting tumour progression and evading cell death. There is significant cross talk between autophagy and a plethora of critical cellular pathways, many of which are dysregulated in pHGG. The following article will discuss our current understanding of autophagy signalling in pHGG and the potential modulation of this network as a therapeutic target.",

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AU - Howarth, Alison

AU - Madureira, Patricia A.

AU - Lockwood, George

AU - Storer, Lisa C. D.

AU - Grundy, Richard

AU - Rahman, Ruman

AU - Pilkington, Geoffrey J.

AU - Hill, Richard

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N2 - Paediatric high grade glioma (pHGG) represent a therapeutically challenging group of tumours. Despite decades of research there has been a minimal improvement in treatment and the clinical prognosis remains poor. Autophagy, a highly conserved process for recycling metabolic substrates is upregulated in pHGG, promoting tumour progression and evading cell death. There is significant cross talk between autophagy and a plethora of critical cellular pathways, many of which are dysregulated in pHGG. The following article will discuss our current understanding of autophagy signalling in pHGG and the potential modulation of this network as a therapeutic target.

AB - Paediatric high grade glioma (pHGG) represent a therapeutically challenging group of tumours. Despite decades of research there has been a minimal improvement in treatment and the clinical prognosis remains poor. Autophagy, a highly conserved process for recycling metabolic substrates is upregulated in pHGG, promoting tumour progression and evading cell death. There is significant cross talk between autophagy and a plethora of critical cellular pathways, many of which are dysregulated in pHGG. The following article will discuss our current understanding of autophagy signalling in pHGG and the potential modulation of this network as a therapeutic target.

U2 - 10.1111/bpa.12729

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M3 - Review article

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SN - 1015-6305

JO - Brain Pathology

JF - Brain Pathology

ER -

Modulating autophagy as a therapeutic strategy for the treatment of paediatric high grade glioma

Abstract

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