Modulation of intestinal epithelial defense responses by probiotic bacteria

L. Y. M. Wan, Z. J. Chen, N. P. Shah, H. El-Nezami

Research output: Contribution to journalArticlepeer-review

Abstract

Probiotics are live microorganisms, which when administered in food confer numerous health benefits. In previous studies about beneficial effects of probiotic bacteria to health, particularly in the fields of intestinal mucosa defense responses, specific probiotics, in a strain-dependent manner, show certain degree of potential to reinforce the integrity of intestinal epithelium and/or regulate some immune components. The mechanism of probiotic action is an area of interest. Among all possible routes of modulation by probiotics of intestinal epithelial cell-mediated defense responses, modulations of intestinal barrier function, innate, and adaptive mucosal immune responses, as well as signaling pathways are considered to play important role in the intestinal defense responses against pathogenic bacteria. This review summarizes the beneficial effects of probiotic bacteria to intestinal health together with the mechanisms affected by probiotic bacteria: barrier function, innate, and adaptive defense responses such as secretion of mucins, defensins, trefoil factors, immunoglobulin A (IgA), Toll-like receptors (TLRs), cytokines, gut associated lymphoid tissues, and signaling pathways.
Original languageEnglish
Pages (from-to)2628-2641
Number of pages14
JournalCritical Reviews in Food Science and Nutrition
Volume56
Issue number16
Early online date28 Jan 2015
DOIs
Publication statusPublished - 9 Dec 2016

Keywords

  • probiotics
  • intestinal epithelia
  • mucosal immunity
  • innate immunity
  • adaptive immunity

Fingerprint

Dive into the research topics of 'Modulation of intestinal epithelial defense responses by probiotic bacteria'. Together they form a unique fingerprint.

Cite this