Molecular pathology and its relevance to thyroid FNA

David Poller; Sharon Glaysher

doi:10.1111/cyt.12492

Molecular pathology and its relevance to thyroid FNA

David Poller, Sharon Glaysher

Research output: Contribution to journal › Literature review › peer-review

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Abstract

This review summarises molecular pathological techniques applicable to thyroid FNA. The molecular pathology of thyroid tumours is now fairly well understood. Molecular methods may be used as a rule-in test for diagnosis of malignancy in thyroid nodules e.g. BRAF V600E point mutation, use of a 7 gene mutational panel (BRAF V600E, RAS genes, RET/PTC or PAX8/PPARG rearrangement), or as a comprehensive multigene next-generation sequencing panel e.g. ThyroSeq v2. Molecular methods can also be applied as rule-out tests for malignancy in thyroid nodules e.g. Afirma or ThyroSeq v2 or as markers of prognosis e.g. TERT promoter mutation or other gene mutations including BRAF V600E, TP53 & AKT1 and as tests for newly defined tumour entities such as NIFTP, or as a molecular marker(s) for targeted therapies. This review describes practical examples of molecular techniques as applied to thyroid FNA in routine clinical practice.

Original language	English
Pages (from-to)	475-481
Number of pages	7
Journal	Cytopathology
Volume	28
Issue number	6
Early online date	22 Nov 2017
DOIs	https://doi.org/10.1111/cyt.12492
Publication status	Published - 1 Dec 2017

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

diagnosis
fine-needle aspiration
molecular
neoplasms
pathology
thyroid

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10.1111/cyt.12492

Molecular_Pathology_in_thyroid_FNA_Final
This is the peer reviewed version of the following article: Poller DN, Glaysher S. Molecular pathology and thyroid FNA. Cytopathology. 2017;28:475–481, which has been published in final form at DOI:10.1111/cyt.12492. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Accepted author manuscript (Post-print), 791 KB

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abstract = "This review summarises molecular pathological techniques applicable to thyroid FNA. The molecular pathology of thyroid tumours is now fairly well understood. Molecular methods may be used as a rule-in test for diagnosis of malignancy in thyroid nodules e.g. BRAF V600E point mutation, use of a 7 gene mutational panel (BRAF V600E, RAS genes, RET/PTC or PAX8/PPARG rearrangement), or as a comprehensive multigene next-generation sequencing panel e.g. ThyroSeq v2. Molecular methods can also be applied as rule-out tests for malignancy in thyroid nodules e.g. Afirma or ThyroSeq v2 or as markers of prognosis e.g. TERT promoter mutation or other gene mutations including BRAF V600E, TP53 \& AKT1 and as tests for newly defined tumour entities such as NIFTP, or as a molecular marker(s) for targeted therapies. This review describes practical examples of molecular techniques as applied to thyroid FNA in routine clinical practice.",

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KW - molecular

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Molecular pathology and its relevance to thyroid FNA

Abstract

UN SDGs

Keywords

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