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Morphology of oligodendroglial cells

  • Arthur Butt*
  • , Adam Willis
  • , Rachel Stevens
  • , Ian Hunter
  • , Akiko Nishiyama*
  • *Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract

Oligodendrocytes are cells in the central nervous system that are specialised to form myelin sheaths around axons. They are generated from oligodendrocyte precursor cells that persist in the adult brain and are responsible for myelin plasticity that is essential for learning and repair in pathology. Oligodendrocytes exhibit morphological and molecular heterogeneity, and, besides their role in myelination, they provide metabolic and homeostatic support for neurones. In addition, some oligodendrocytes exhibit an immune function as antigen-presenting cells under certain conditions. The myelinating function of oligodendrocytes is essential for nervous system operational integrity, and the loss of myelin leads to neurodegeneration and an irreversible loss of function.

Original languageEnglish
Title of host publicationPhysiology and Pathophysiology of Oligodendroglia
EditorsChenju Yi, Arthur Butt, Alexei Verkhrastsky, Jianqin Niu
PublisherSpringer Cham
Pages97-123
Number of pages27
Edition1st
ISBN (Electronic)9783031879197
ISBN (Print)9783031879180, 9783031879210
DOIs
Publication statusPublished - 12 Jun 2025

Publication series

NameAdvances in Neurobiology
Volume43
ISSN (Print)2190-5215
ISSN (Electronic)2190-5223

Keywords

  • Axon
  • Myelin
  • Neurone
  • Oligodendrocyte
  • Oligodendrocyte precursor cell
  • Oligodendroglia
  • Perineuronal oligodendrocyte
  • Satellite oligodendrocyte

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