Mucin/poly(acrylic acid) interactions: A spectroscopic investigation of mucoadhesion

Minesh M. Patel; John D. Smart; Thomas G. Nevell; Richard J. Ewen; P. J. Eaton; John Tsibouklis

doi:10.1021/bm034028p

Mucin/poly(acrylic acid) interactions: A spectroscopic investigation of mucoadhesion

Minesh M. Patel, John D. Smart, Thomas G. Nevell^*, Richard J. Ewen, P. J. Eaton, John Tsibouklis

^*Corresponding author for this work

Institute of Life Sciences and Healthcare

Research output: Contribution to journal › Article › peer-review

Abstract

Studies using infrared, ¹H and ¹³C nuclear magnetic resonance, and X-ray photoelectron spectroscopies and differential scanning calorimetry support the hypothesis that hydrogen bonds, formed between the carboxylic acid functionality of the mucoadhesive material poly(acrylic acid) and the glycoprotein component of mucus, play a significant role in the process of mucoadhesion. There are fewer H-bonded interactions between the components than within the bulk of the pure mucoadhesive agent. The pH of the medium influences the structures of both the poly(acrylic acid) and the mucus, which, in turn, determine the nature and the extent of mucoadhesive interactions.

Original language	English
Pages (from-to)	1184-1190
Number of pages	7
Journal	Biomacromolecules
Volume	4
Issue number	5
DOIs	https://doi.org/10.1021/bm034028p
Publication status	Published - 1 Sept 2003

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abstract = "Studies using infrared, 1H and 13C nuclear magnetic resonance, and X-ray photoelectron spectroscopies and differential scanning calorimetry support the hypothesis that hydrogen bonds, formed between the carboxylic acid functionality of the mucoadhesive material poly(acrylic acid) and the glycoprotein component of mucus, play a significant role in the process of mucoadhesion. There are fewer H-bonded interactions between the components than within the bulk of the pure mucoadhesive agent. The pH of the medium influences the structures of both the poly(acrylic acid) and the mucus, which, in turn, determine the nature and the extent of mucoadhesive interactions.",

author = "Patel, {Minesh M.} and Smart, {John D.} and Nevell, {Thomas G.} and Ewen, {Richard J.} and Eaton, {P. J.} and John Tsibouklis",

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T2 - A spectroscopic investigation of mucoadhesion

AU - Patel, Minesh M.

AU - Smart, John D.

AU - Nevell, Thomas G.

AU - Ewen, Richard J.

AU - Eaton, P. J.

AU - Tsibouklis, John

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Studies using infrared, 1H and 13C nuclear magnetic resonance, and X-ray photoelectron spectroscopies and differential scanning calorimetry support the hypothesis that hydrogen bonds, formed between the carboxylic acid functionality of the mucoadhesive material poly(acrylic acid) and the glycoprotein component of mucus, play a significant role in the process of mucoadhesion. There are fewer H-bonded interactions between the components than within the bulk of the pure mucoadhesive agent. The pH of the medium influences the structures of both the poly(acrylic acid) and the mucus, which, in turn, determine the nature and the extent of mucoadhesive interactions.

AB - Studies using infrared, 1H and 13C nuclear magnetic resonance, and X-ray photoelectron spectroscopies and differential scanning calorimetry support the hypothesis that hydrogen bonds, formed between the carboxylic acid functionality of the mucoadhesive material poly(acrylic acid) and the glycoprotein component of mucus, play a significant role in the process of mucoadhesion. There are fewer H-bonded interactions between the components than within the bulk of the pure mucoadhesive agent. The pH of the medium influences the structures of both the poly(acrylic acid) and the mucus, which, in turn, determine the nature and the extent of mucoadhesive interactions.

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AN - SCOPUS:0141615077

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EP - 1190

JO - Biomacromolecules

JF - Biomacromolecules

IS - 5

ER -

Mucin/poly(acrylic acid) interactions: A spectroscopic investigation of mucoadhesion

Abstract

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