Mucin/poly(acrylic acid) interactions: A spectroscopic investigation of mucoadhesion

Minesh M. Patel, John D. Smart, Thomas G. Nevell*, Richard J. Ewen, P. J. Eaton, John Tsibouklis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Studies using infrared, 1H and 13C nuclear magnetic resonance, and X-ray photoelectron spectroscopies and differential scanning calorimetry support the hypothesis that hydrogen bonds, formed between the carboxylic acid functionality of the mucoadhesive material poly(acrylic acid) and the glycoprotein component of mucus, play a significant role in the process of mucoadhesion. There are fewer H-bonded interactions between the components than within the bulk of the pure mucoadhesive agent. The pH of the medium influences the structures of both the poly(acrylic acid) and the mucus, which, in turn, determine the nature and the extent of mucoadhesive interactions.

Original languageEnglish
Pages (from-to)1184-1190
Number of pages7
Issue number5
Publication statusPublished - 1 Sept 2003


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