TY - JOUR
T1 - Mucoadhesive, triclosan-loaded polymer microspheres for application to the oral cavity
T2 - Preparation and controlled release characteristics
AU - Kockisch, Sandra
AU - Rees, Gareth D.
AU - Tsibouklis, John
AU - Smart, John D.
PY - 2005/1/1
Y1 - 2005/1/1
N2 - The aim of this study was to develop mucoadhesive microspheres that can be utilised for the controlled release of triclosan in oral-care formulations, specifically dental pastes. Using a double-emulsion solvent evaporation technique, triclosan was incorporated into microspheres that were prepared from Gantrez™ MS-955, Carbopol™ 974P, polycarbophil or chitosan and the profiles for its release were established under simulated 'in use' conditions. Triclosan was rapidly released into a sodium lauryl sulphate containing buffer from all but the chitosan microspheres. The release of triclosan from microspheres suspended in a non-aqueous paste, was found to be sustained over considerable time-periods, which were influenced strongly by the nature of the polymeric carrier. For microspheres that were fabricated from Gantrez, Carbopol or polycarbophil, the release appeared to obey zero-order kinetics whereas in the case of chitosan-derived vehicles, the release profile fitted the Baker and Lonsdale model. The work has demonstrated that these polymeric microspheres, particularly those of chitosan, are promising candidates for the sustained release of triclosan in the oral cavity.
AB - The aim of this study was to develop mucoadhesive microspheres that can be utilised for the controlled release of triclosan in oral-care formulations, specifically dental pastes. Using a double-emulsion solvent evaporation technique, triclosan was incorporated into microspheres that were prepared from Gantrez™ MS-955, Carbopol™ 974P, polycarbophil or chitosan and the profiles for its release were established under simulated 'in use' conditions. Triclosan was rapidly released into a sodium lauryl sulphate containing buffer from all but the chitosan microspheres. The release of triclosan from microspheres suspended in a non-aqueous paste, was found to be sustained over considerable time-periods, which were influenced strongly by the nature of the polymeric carrier. For microspheres that were fabricated from Gantrez, Carbopol or polycarbophil, the release appeared to obey zero-order kinetics whereas in the case of chitosan-derived vehicles, the release profile fitted the Baker and Lonsdale model. The work has demonstrated that these polymeric microspheres, particularly those of chitosan, are promising candidates for the sustained release of triclosan in the oral cavity.
KW - Bioadhesion
KW - Double emulsion
KW - Oral cavity
KW - Polymer microspheres
KW - Release kinetics
KW - Triclosan
UR - http://www.scopus.com/inward/record.url?scp=9644287768&partnerID=8YFLogxK
U2 - 10.1016/j.ejpb.2004.07.007
DO - 10.1016/j.ejpb.2004.07.007
M3 - Article
C2 - 15567319
AN - SCOPUS:9644287768
SN - 0939-6411
VL - 59
SP - 207
EP - 216
JO - European Journal of Pharmaceutics and Biopharmaceutics
JF - European Journal of Pharmaceutics and Biopharmaceutics
IS - 1
ER -