Myb induced myeloid protein 1 (Mim-1) is an acetyltransferase

S. Allen, Tim Hebbes

Research output: Contribution to journalArticlepeer-review


We have screened protein extracts from chicken blood cells for acetyltransferases. An in gel acetyltransferase assay revealed that a 32 kDa protein, which is more prevalent in whole blood when compared with erythrocyte cells, possessed an auto-acetylation activity. This protein was purified by a series of chromatographic steps, sequenced by Edman degradation and subsequently identified as Myb induced myeloid protein (Mim-1). Mim-1 has similarities to the conserved acetyltransferase motifs found in the GNAT superfamily of proteins and also contains three minimal GK acetylation motifs. These data identify Mim-1 as an acetyltransferase.
Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalFEBS Letters
Issue number1-3
Publication statusPublished - 2003


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