Nanotechnology enables the miniaturization of complex devices designed to enhance individuals’ physical and cognitive capabilities and, in the form of nanoimplants, their integration in the human body. It is unknown, however, whether people are willing or not to accept such devices. To shed light on this issue, this research used an extended version of the well-known technology acceptance model (TAM), adding affective factors to the cognitive components already present in the model. Testing on a sample of 600 individuals yielded statistically significant effects on attitudes toward nanoimplants and intention to undergo nanoimplantation. Conclusions are drawn and implications are discussed.