Nitrate tolerance and the links with endothelial dysfunction and oxidative stress

K. Fayers, M. Cummings, K. Shaw, David Laight

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Abstract

Identification of nitric oxide as the molecule responsible for endothelial dependant vasodilatation has led to an explosion of interest in endothelial function. Oxidative stress has been identified as an important factor in the development of tolerance to organic nitrates. This review examines the evidence supporting this recently developed theory and how mechanisms of nitrate tolerance may link with the wider picture of primary nitric oxide resistance.
Original languageEnglish
Pages (from-to)620-628
Number of pages9
JournalBritish Journal of Clinical Pharmacology
Volume56
Issue number6
DOIs
Publication statusPublished - Dec 2003

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