Nitrate tolerance and the links with endothelial dysfunction and oxidative stress

K. Fayers; M. Cummings; K. Shaw; David Laight

doi:10.1046/j.1365-2125.2003.01946.x

Nitrate tolerance and the links with endothelial dysfunction and oxidative stress

K. Fayers, M. Cummings, K. Shaw, David Laight

School of Pharmacy & Biomedical Sciences

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Abstract

Identification of nitric oxide as the molecule responsible for endothelial dependant vasodilatation has led to an explosion of interest in endothelial function. Oxidative stress has been identified as an important factor in the development of tolerance to organic nitrates. This review examines the evidence supporting this recently developed theory and how mechanisms of nitrate tolerance may link with the wider picture of primary nitric oxide resistance.

Original language	English
Pages (from-to)	620-628
Number of pages	9
Journal	British Journal of Clinical Pharmacology
Volume	56
Issue number	6
DOIs	https://doi.org/10.1046/j.1365-2125.2003.01946.x
Publication status	Published - Dec 2003

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title = "Nitrate tolerance and the links with endothelial dysfunction and oxidative stress",

abstract = "Identification of nitric oxide as the molecule responsible for endothelial dependant vasodilatation has led to an explosion of interest in endothelial function. Oxidative stress has been identified as an important factor in the development of tolerance to organic nitrates. This review examines the evidence supporting this recently developed theory and how mechanisms of nitrate tolerance may link with the wider picture of primary nitric oxide resistance.",

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AU - Shaw, K.

AU - Laight, David

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AB - Identification of nitric oxide as the molecule responsible for endothelial dependant vasodilatation has led to an explosion of interest in endothelial function. Oxidative stress has been identified as an important factor in the development of tolerance to organic nitrates. This review examines the evidence supporting this recently developed theory and how mechanisms of nitrate tolerance may link with the wider picture of primary nitric oxide resistance.

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DO - 10.1046/j.1365-2125.2003.01946.x

M3 - Article

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EP - 628

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 6

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Nitrate tolerance and the links with endothelial dysfunction and oxidative stress

Abstract

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